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    Csnk2b casein kinase 2, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 13001, updated on 12-May-2024

    Summary

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    Official Symbol
    Csnk2bprovided by MGI
    Official Full Name
    casein kinase 2, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:88548
    See related
    Ensembl:ENSMUSG00000024387 AllianceGenome:MGI:88548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK II beta
    Summary
    This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in testis adult (RPKM 540.1), duodenum adult (RPKM 75.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csnk2b in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35335171..35341029, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35116195..35122053, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene predicted gene 20522 Neighboring gene DNA segment, Chr 17, human D6S53E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice. Liang QX, et al. Cell Prolif, 2020 Jan. PMID 31755150, Free PMC Article
    2. A proteomics analysis of CK2β((-/-)) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit. Borgo C, et al. FEBS J, 2019 Apr. PMID 30834696
    3. Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure. Liang QX, et al. Cell Death Dis, 2018 May 1. PMID 29725001, Free PMC Article
    4. CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis. Münzer P, et al. Blood, 2017 Dec 21. PMID 28928125
    5. Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Bragdon B, et al. Biophys J, 2010 Aug 4. PMID 20682268, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
      Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
    2. Results found that the regulatory CK2 beta subunits are essential for GN11 neuronal cell migration and their deletion induces deep changes in cytoskeletal structures that totally prevent cell migration.
      Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
    3. pool of ecto-CK2 is not apparently affected by the lack of the beta-subunit
      Title: A proteomics analysis of CK2β((-/-)) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit.
    4. Ablation of Ck2beta gene triggered excessive germ cell apoptosis, germ cell development arrest, azoospermia and male infertility. Inactivation of Ck2beta gene caused distinctly reduced expression of Ck2alpha' gene and CK2alpha' protein.
      Title: Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice.
    5. Oocyte-specific deletion of CK2beta causes follicular atresia and premature ovarian failure in mice.
      Title: Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure.
    6. GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons.
      Title: Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.
    7. thrombotic vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time
      Title: CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis.
    8. AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury.
      Title: AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β.
    9. These data suggest that CK2 is a negative regulator of BMP signaling and osteoblast differentiation.
      Title: Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling.
    10. Data suggest that CK2beta appears to play an essential and uncompensated role in central nervous system development.
      Title: Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Ly6g5b

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont-mediated disruption of host cell PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase II subunit beta
    Names
    phosvitin
    NP_001290374.1
    NP_001290375.1
    NP_001290405.1
    NP_034105.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303445.1 → NP_001290374.1  casein kinase II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001290374.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28684.1
      UniProtKB/Swiss-Prot
      P67871, Q3TTJ7
      UniProtKB/TrEMBL
      N0E4C0
      Related
      ENSMUSP00000134218.2, ENSMUST00000173114.8
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    2. NM_001303446.1 → NP_001290375.1  casein kinase II subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001290375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      N0E4C0
      Related
      ENSMUSP00000134523.3, ENSMUST00000172765.9
      Conserved Domains (1) summary
      smart01085
      Location:29 → 212
      CK_II_beta; Casein kinase II regulatory subunit

    3. NM_001303476.1 → NP_001290405.1  casein kinase II subunit beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region compared to variant 1, including initiation of translation at a downstream start codon. It encodes isoform 3, which is longer than isoform 1 and has a shorter N-terminus and a distinct C-terminus.
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS79541.1
      UniProtKB/TrEMBL
      G3UZX4
      Related
      ENSMUSP00000134673.2, ENSMUST00000174024.8
      Conserved Domains (1) summary
      smart01085
      Location:8 → 129
      CK_II_beta; Casein kinase II regulatory subunit

    4. NM_009975.3 → NP_034105.1  casein kinase II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_034105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28684.1
      UniProtKB/Swiss-Prot
      P67871, Q3TTJ7
      UniProtKB/TrEMBL
      N0E4C0
      Related
      ENSMUSP00000025246.7, ENSMUST00000025246.13
      Conserved Domains (1) summary
      smart01085
      Location:8 → 191
      CK_II_beta; Casein kinase II regulatory subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35335171..35341029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P67871.1 GenPept UniProtKB/Swiss-Prot:P67871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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