Cysltr1 cysteinyl leukotriene receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cysltr1provided by RGD
Official Full Name: cysteinyl leukotriene receptor 1provided by RGD
Primary source: RGD:619796
See related: Ensembl:ENSRNOG00000037845 AllianceGenome:RGD:619796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyslt1
Summary: Enables leukotriene receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to be integral component of plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 30.4), Heart (RPKM 23.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (75734281..75762873, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (71661421..71690012, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (77671028..77700491, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cysteinyl leukotriene receptor-1 antagonist montelukast prevents estradiol-induced nonbacterial inflammation in the rat prostate.
Title: The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.
The expression of CysLT(1) receptor increased after rotenone treatment of PC12 cells.
Title: [Cysteinyl leukotriene receptor 1 is involved in rotenone-induced injury of PC12 cells].
abolishing leukotriene receptor desensitization suppresses agonist-driven gene expression in a rat cell line
Title: Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression.
At 0 to 3 hours after renal ischemia-reperfusion, CysLT1R expression on endothelial cells gradually became stronger, being most intense at 3 hours after reperfusion
Title: Study of cysteinyl leukotriene-1 receptor in rat renal ischemia-reperfusion injury.
Thus, we conclude that cysteinyl leukotriene receptor 1 mediates acute neuronal damage and subacute/chronic astrogliosis after focal cerebral ischemia.
Title: Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteinyl leukotriene receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene receptor activity	IEA Inferred from Electronic Annotation more info
enables leukotriene receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in leukotriene signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteinyl leukotriene receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053641.2 → NP_446093.1 cysteinyl leukotriene receptor 1

See identical proteins and their annotated locations for NP_446093.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q924T8

UniProtKB/TrEMBL

A0A0U1RRX8, A6IV49

Related

ENSRNOP00000075854.2, ENSRNOT00000092418.2

Conserved Domains (1) summary

cd15158
Location:26 → 308

7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors