Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naaladl1provided by RGD
Official Full Name: N-acetylated alpha-linked acidic dipeptidase-like 1provided by RGD
Primary source: RGD:620987
See related: Ensembl:ENSRNOG00000021000 AllianceGenome:RGD:620987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: I100; Naaladasel
Summary: Predicted to enable exopeptidase activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in peptide catabolic process. Located in apical plasma membrane. Is integral component of membrane. Orthologous to human NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 13.5), Adrenal (RPKM 10.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212829917..212843474)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203400632..203414195)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221470675..221484222)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminopeptidase NAALADL1

Names: 100 kDa ileum brush border membrane protein; N-acetylated alpha-linked acidic dipeptidase-like (ileal peptidase I100); N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; ileal dipeptidylpeptidase; ileal peptidase I100

NP_113947.1

EC 3.4.17.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031759.2 → NP_113947.1 aminopeptidase NAALADL1

See identical proteins and their annotated locations for NP_113947.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O54697

UniProtKB/TrEMBL

A6HZD9, A6HZE0

Related

ENSRNOP00000051719.3, ENSRNOT00000054835.4

Conserved Domains (4) summary

cd02121
Location:119 → 331

PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...

cd08022
Location:353 → 592

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

pfam04253
Location:621 → 740

TFR_dimer; Transferrin receptor-like dimerization domain

cl14876
Location:53 → 126

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42