Slc30a1 solute carrier family 30 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a1provided by RGD
Official Full Name: solute carrier family 30 member 1provided by RGD
Primary source: RGD:61918
See related: Ensembl:ENSRNOG00000004749 AllianceGenome:RGD:61918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium channel inhibitor activity and zinc ion transmembrane transporter activity. Involved in detoxification of cadmium ion; metal ion transport; and negative regulation of neurotransmitter secretion. Acts upstream of or within zinc ion transport. Located in T-tubule. Is integral component of membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic density membrane. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 355.5), Kidney (RPKM 321.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (106022019..106025892)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (103491037..103494910)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (110677810..110681683)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia/reoxygenation dramatically decreased ZnT-1 expression in rat astrocytes.
Title: ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke.
These data indicate that maternal zinc deficiency resulted in an elevated incidence of fetal heart malformations, which was associated with significant decreases in placental MT-1 and ZnT-1 mRNA expressions
Title: Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency.
ZNT-1 interacts with GluN2A-containing NMDA receptors at the glutamatergic synapse. This complex is regulated by synaptic plasticity induction. ZNT-1 expression modulation in hippocampal neurons shrank dendritic spines and reduced GluN2A surface levels.
Title: Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density.
The mRNA levels of ZnT-1 and BDNF were significantly increased in spinal cord injury model group.
Title: The correlation among the dynamic change of Zn2+, ZnT-1, and brain-derived neurotrophic factor after acute spinal cord injury in rats.
ZnT-1 expression is crucial for maintaining zinc homeostasis, in particular, for the enhanced retention of zinc in transformed cells when subjected to zinc deprivation.
Title: The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells.
These data are consistent with an important role for ZnT-1, ZnT-3 and PRG-1 in the pathophysiology of the long-term adverse effects of recurrent neonatal seizure-induced hippocampal mossy fiber sprouting and cognitive deficit.
Title: Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures.
show that rapid electrical pacing can augment ZnT-1 expression in culture as well as in the atria of rats in vivo.
Title: The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected].
zinc transporter 1 is an endogenous inhibitor of L-type calcium channels
Title: Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels.
ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
Title: ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
findings suggest that ZnT1 plays a direct role in Zn2+ efflux in cultured cortical neurons
Title: Silencing of ZnT1 reduces Zn2+ efflux in cultured cortical neurons.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of zinc ion transmembrane import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density protein 95 clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into organelle	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in glutamatergic postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A1

Names: solute carrier family 30 (zinc transporter), member 1; zinc transporter 1; znT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022853.2 → NP_074044.1 proton-coupled zinc antiporter SLC30A1

See identical proteins and their annotated locations for NP_074044.1

Status: PROVISIONAL

Source sequence(s)

U17133

UniProtKB/Swiss-Prot

Q62720

Related

ENSRNOP00000006340.2, ENSRNOT00000006340.5

Conserved Domains (2) summary

COG1230
Location:6 → 422

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:21 → 343

Cation_efflux; Cation efflux family