Pde4a phosphodiesterase 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pde4aprovided by RGD
Official Full Name: phosphodiesterase 4Aprovided by RGD
Primary source: RGD:3279
See related: Ensembl:ENSRNOG00000020828 AllianceGenome:RGD:3279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DPDE2; PHOSA
Summary: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and cAMP binding activity. Involved in modulation of chemical synaptic transmission and response to xenobiotic stimulus. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 72.2), Heart (RPKM 63.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27966978..28029721)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19690816..19753538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22189533..22234036)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
Title: Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
Title: In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
Selective changes in cytosolic beta-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy.
Title: Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy.
ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion.
Title: ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion.
PDE4A upregulation during cholestatic liver injury plays a role in inflammation and fibrosis.
Title: Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.
beta-adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
Title: β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population.
Title: Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
Title: In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
cGMP and cAMP phosphodiesterase PDE4 and AMPK/NOX2 have a role in early cardiac hypertrophy induced by angiotensin II
Title: Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.
unique tissue distribution of PDE4A8, combined with the evolutionary divergence of its N-terminus, suggest that this isoform may have a specific function in regulating cAMP levels in human skeletal muscle and brain
Title: Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94489 (e-PCR)
- UniSTS:119737

BF391741 (e-PCR)
- UniSTS:249822

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cAMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3',5'-cyclic-AMP phosphodiesterase 4A

Names: PDE4A10 cAMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)

NP_001380664.1

EC 3.1.4.53

NP_001380665.1

EC 3.1.4.53

NP_001380666.1

EC 3.1.4.53

NP_037233.4

EC 3.1.4.53

XP_063121035.1

EC 3.1.4.53

XP_063121036.1

EC 3.1.4.53

XP_063121037.1

EC 3.1.4.53

XP_063121038.1

EC 3.1.4.53

XP_063121039.1

EC 3.1.4.53

XP_063121040.1

EC 3.1.4.53

XP_063121041.1

EC 3.1.4.53

XP_063121042.1

EC 3.1.4.53

XP_063121043.1

EC 3.1.4.53

XP_063121044.1

EC 3.1.4.53

XP_063121045.1

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393735.1 → NP_001380664.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P14645, P54748, Q9EQR7

UniProtKB/TrEMBL

A6JNQ0

Related

ENSRNOP00000085157.1, ENSRNOT00000109272.1

Conserved Domains (2) summary

pfam00233
Location:361 → 602

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:116 → 231

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001393736.1 → NP_001380665.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P14645, P54748, Q9EQR7

UniProtKB/TrEMBL

A0A8I5ZV79, A6JNP8

Related

ENSRNOP00000082776.1, ENSRNOT00000096283.1

Conserved Domains (2) summary

pfam00233
Location:337 → 578

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:92 → 207

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001393737.1 → NP_001380666.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZUU0, A0A8I6GFN4

Related

ENSRNOP00000082374.1, ENSRNOT00000112455.1

Conserved Domains (2) summary

pfam00233
Location:184 → 425

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:22 → 54

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_013101.4 → NP_037233.4 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P14645, P54748, Q9EQR7

UniProtKB/TrEMBL

A6JNP9, F1M8I9

Related

ENSRNOP00000057815.5, ENSRNOT00000061100.6

Conserved Domains (2) summary

pfam00233
Location:418 → 659

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:173 → 288

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

27966978..28029721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264966.1 → XP_063121036.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X2
XM_063264971.1 → XP_063121041.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X4

UniProtKB/TrEMBL

A0A8I5ZV79, A6JNP8
XM_063264967.1 → XP_063121037.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X2
XM_063264972.1 → XP_063121042.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X4

UniProtKB/TrEMBL

A0A8I5ZV79, A6JNP8
XM_063264970.1 → XP_063121040.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

UniProtKB/TrEMBL

A0A8I5ZZJ4
XM_063264975.1 → XP_063121045.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X7
XM_063264965.1 → XP_063121035.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X1

UniProtKB/TrEMBL

A0A8I6ALZ5
XM_063264969.1 → XP_063121039.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

UniProtKB/TrEMBL

A0A8I5ZZJ4
XM_063264968.1 → XP_063121038.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X3

UniProtKB/TrEMBL

A0A8I5ZZJ4
XM_063264973.1 → XP_063121043.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X5
XM_063264974.1 → XP_063121044.1 3',5'-cyclic-AMP phosphodiesterase 4A isoform X6