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    Mgat4c MGAT4 family, member C [ Mus musculus (house mouse) ]

    Gene ID: 67569, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mgat4cprovided by MGI
    Official Full Name
    MGAT4 family, member Cprovided by MGI
    Primary source
    MGI:MGI:1914819
    See related
    Ensembl:ENSMUSG00000019888 AllianceGenome:MGI:1914819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GntIVh; 9130411I17Rik
    Summary
    Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Orthologous to human MGAT4C (MGAT4 family member C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 3.5), colon adult (RPKM 2.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgat4c in Genome Data Viewer
    Location:
    10 D1; 10 52.92 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (101517348..102227712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (101681487..102391851)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27741 Neighboring gene predicted gene, 26278 Neighboring gene microRNA 3059 Neighboring gene STARR-seq mESC enhancer starr_27742 Neighboring gene STARR-seq mESC enhancer starr_27743 Neighboring gene STARR-seq mESC enhancer starr_27744 Neighboring gene STARR-seq mESC enhancer starr_27745 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene neurotensin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article
    2. Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Petitpré C, et al. Nat Commun, 2022 Jul 5. PMID 35790771, Free PMC Article
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
    Names
    N-acetylglucosaminyltransferase IVc
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
    UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc
    gnT-IVc
    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
    NP_001155840.1
    NP_001155841.1
    NP_001192027.1
    NP_080519.2
    XP_006514065.1
    XP_006514066.1
    XP_006514067.1
    XP_006514068.1
    XP_011241840.1
    XP_030101095.1
    XP_030101096.1
    XP_036011857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162368.2 → NP_001155840.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      See identical proteins and their annotated locations for NP_001155840.1

      Status: VALIDATED

      Source sequence(s)
      AC133175, AC168058
      Consensus CDS
      CCDS24153.1
      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Related
      ENSMUSP00000131551.2, ENSMUST00000163753.8
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    2. NM_001162369.2 → NP_001155841.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      See identical proteins and their annotated locations for NP_001155841.1

      Status: VALIDATED

      Source sequence(s)
      AC133175, AC168058
      Consensus CDS
      CCDS24153.1
      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Related
      ENSMUSP00000020039.7, ENSMUST00000020039.13
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    3. NM_001205098.2 → NP_001192027.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      See identical proteins and their annotated locations for NP_001192027.1

      Status: VALIDATED

      Source sequence(s)
      AC153502, AC153932, AC168058
      Consensus CDS
      CCDS24153.1
      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    4. NM_001429516.1 → NP_001416445.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      Status: VALIDATED

      Source sequence(s)
      AC133175, AC168058

    5. NM_001429517.1 → NP_001416446.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      Status: VALIDATED

      Source sequence(s)
      AC153502, AC153932, AC168058

    6. NM_026243.5 → NP_080519.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

      See identical proteins and their annotated locations for NP_080519.2

      Status: VALIDATED

      Source sequence(s)
      AC168058
      Consensus CDS
      CCDS24153.1
      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Related
      ENSMUSP00000114010.2, ENSMUST00000120748.2
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    RNA

    1. NR_190742.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153502, AC153932, AC160559

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      101517348..102227712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514002.1 → XP_006514065.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    2. XM_036155964.1 → XP_036011857.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    3. XM_006514003.1 → XP_006514066.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      See identical proteins and their annotated locations for XP_006514066.1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    4. XM_030245235.1 → XP_030101095.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    5. XM_006514005.3 → XP_006514068.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      See identical proteins and their annotated locations for XP_006514068.1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    6. XM_030245236.1 → XP_030101096.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    7. XM_011243538.4 → XP_011241840.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      See identical proteins and their annotated locations for XP_011241840.1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    8. XM_006514004.4 → XP_006514067.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

      See identical proteins and their annotated locations for XP_006514067.1

      UniProtKB/Swiss-Prot
      Q9D2X2, Q9D306
      Conserved Domains (1) summary
      pfam04666
      Location:64 → 330
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D306.1 GenPept UniProtKB/Swiss-Prot:Q9D306

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