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    Drg2 developmentally regulated GTP binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497915, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Drg2provided by RGD
    Official Full Name
    developmentally regulated GTP binding protein 2provided by RGD
    Primary source
    RGD:1562380
    See related
    Ensembl:ENSRNOG00000055309 AllianceGenome:RGD:1562380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562380
    Summary
    Predicted to enable GTPase activity and RNA binding activity. Predicted to be located in cytosol and nucleoplasm. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 152.4), Thymus (RPKM 146.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Drg2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45755072..45769493)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45255512..45269971)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46818412..46831308)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene GID complex subunit 4 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene myosin XVA Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L17 like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Markolovic S, et al. Nat Chem Biol, 2018 Jul. PMID 29915238, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    developmentally-regulated GTP-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398843.1 → NP_001385772.1  developmentally-regulated GTP-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZWK0, A6HF46
      Related
      ENSRNOP00000084115.1, ENSRNOT00000104762.1
      Conserved Domains (1) summary
      COG1163
      Location:1 → 364
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45755072..45769493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087262.2 → XP_038943190.1  developmentally-regulated GTP-binding protein 2 isoform X1

      Conserved Domains (1) summary
      COG1163
      Location:1 → 283
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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