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    Ccnc cyclin C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114839, updated on 2-May-2024

    Summary

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    Official Symbol
    Ccncprovided by RGD
    Official Full Name
    cyclin Cprovided by RGD
    Primary source
    RGD:70905
    See related
    Ensembl:ENSRNOG00000007719 AllianceGenome:RGD:70905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Located in nucleus. Part of ubiquitin ligase complex. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 129.0), Brain (RPKM 120.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccnc in Genome Data Viewer
    Location:
    5q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40063589..40081731)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35266828..35284943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (35865598..35883732)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene PR/SET domain 13 Neighboring gene uncharacterized LOC120102842 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene uncharacterized LOC134478949 Neighboring gene ubiquitin specific peptidase 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Influence of aerosols on the expression of cyclin B1, cyclin C and proliferating cell nuclear antigen in wound tissue healing of burned rat models]. Zhang T, et al. Zhonghua Wai Ke Za Zhi, 2005 Oct 1. PMID 16271231
    2. Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis. Rao HV, et al. Neurosci Lett, 2009 Feb 6. PMID 19103257, Free PMC Article
    3. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. Li H, et al. Genomics, 1996 Mar 1. PMID 8833152
    4. Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Demetrick DJ, et al. Cytogenet Cell Genet, 1995. PMID 7698009
    5. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Tamura K, et al. Oncogene, 1993 Aug. PMID 8336937

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G0 to G1 transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CKM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CKM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100472.1 → NP_001093942.1  cyclin-C

      See identical proteins and their annotated locations for NP_001093942.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P39947
      UniProtKB/TrEMBL
      A6IIE2, G3V738
      Related
      ENSRNOP00000011442.5, ENSRNOT00000011442.7
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      40063589..40081731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237937.5 → XP_006237999.1  cyclin-C isoform X2

      See identical proteins and their annotated locations for XP_006237999.1

      UniProtKB/Swiss-Prot
      P39947
      UniProtKB/TrEMBL
      A0A8I6A408, A6IIE3
      Related
      ENSRNOP00000086557.1
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    2. XM_039109128.2 → XP_038965056.1  cyclin-C isoform X2

      UniProtKB/Swiss-Prot
      P39947
      UniProtKB/TrEMBL
      A0A8I6A408, A6IIE3
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    3. XM_063287061.1 → XP_063143131.1  cyclin-C isoform X1

    4. XM_063287062.1 → XP_063143132.1  cyclin-C isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39947.2 GenPept UniProtKB/Swiss-Prot:P39947

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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