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    C11h21orf91 similar to human chromosome 21 open reading frame 91 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360692, updated on 3-Apr-2024

    Summary

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    Official Symbol
    C11h21orf91provided by RGD
    Official Full Name
    similar to human chromosome 21 open reading frame 91provided by RGD
    Primary source
    RGD:1563888
    See related
    AllianceGenome:RGD:1563888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563888
    Summary
    Predicted to be involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. Orthologous to human C21orf91 (chromosome 21 open reading frame 91). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 93.4), Thymus (RPKM 87.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C11h21orf91 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (30716034..30749292, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (17229129..17262307, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (17073296..17120235, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 3 Neighboring gene uncharacterized LOC120095596 Neighboring gene uncharacterized LOC120095597 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 31 Neighboring gene chondrolectin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Li SS, et al. Sci Rep, 2016 Jul 11. PMID 27404227, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein EURL homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108312.4 → NP_001101782.1  protein EURL homolog

      See identical proteins and their annotated locations for NP_001101782.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JL42
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 283
      EURL; EURL protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      30716034..30749292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088457.2 → XP_038944385.1  protein EURL homolog isoform X2

      Conserved Domains (1) summary
      pfam06937
      Location:14 → 253
      EURL; EURL protein

    2. XM_017598023.3 → XP_017453512.1  protein EURL homolog isoform X1

      UniProtKB/TrEMBL
      A6JL42
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 283
      EURL; EURL protein

    3. XM_008768531.4 → XP_008766753.1  protein EURL homolog isoform X1

      See identical proteins and their annotated locations for XP_008766753.1

      UniProtKB/TrEMBL
      A6JL42
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 283
      EURL; EURL protein
    Nucleotide Protein Strain
    Heading Accession and Version

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