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    Actr1a actin related protein 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294010, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Actr1aprovided by RGD
    Official Full Name
    actin related protein 1Aprovided by RGD
    Primary source
    RGD:1307025
    See related
    Ensembl:ENSRNOG00000019725 AllianceGenome:RGD:1307025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity. Involved in spermatogenesis. Located in COPI-coated vesicle; centriole; and manchette. Orthologous to human ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 502.3), Heart (RPKM 416.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Actr1a in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255179241..255199009, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245237821..245256618, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266123864..266142621, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 10 open reading frame 95 Neighboring gene microRNA 146b Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene uncharacterized LOC134484078 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene uncharacterized LOC134484077

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Application of serex-analysis for identification of human colon cancer antigens. Garifulin OM, et al. Exp Oncol, 2015 Sep. PMID 26422100
    2. Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain. Gulesserian T, et al. Biochem Biophys Res Commun, 2002 Feb 15. PMID 11829462
    3. ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. Fouquet J, et al. J Cell Sci, 2000 Mar. PMID 10671377
    4. Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles. Heimann K, et al. J Biol Chem, 1999 Apr 16. PMID 10196146
    5. Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Kiyomitsu T, et al. Nat Cell Biol, 2012 Feb 12. PMID 22327364, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-centractin
    Names
    ARP1 actin related protein 1 homolog A
    ARP1 actin-related protein 1 homolog A, centractin alpha
    centractin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106364.1 → NP_001099834.1  alpha-centractin

      See identical proteins and their annotated locations for NP_001099834.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/Swiss-Prot
      P85515
      UniProtKB/TrEMBL
      A0A8I6A4H6, A6JHM5
      Related
      ENSRNOP00000026792.6, ENSRNOT00000026792.6
      Conserved Domains (1) summary
      cl17037
      Location:5 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255179241..255199009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287265.1 → XP_063143335.1  alpha-centractin isoform X3

      UniProtKB/Swiss-Prot
      P85515
      UniProtKB/TrEMBL
      A0A8I6A4H6, A6JHM5

    2. XM_063287262.1 → XP_063143332.1  alpha-centractin isoform X2

      UniProtKB/TrEMBL
      A0A8L2UK87

    3. XM_006231470.5 → XP_006231532.1  alpha-centractin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4H6
      Conserved Domains (1) summary
      cl17037
      Location:5 → 396
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_039109087.2 → XP_038965015.1  alpha-centractin isoform X4

      UniProtKB/TrEMBL
      A0A8L2UK87
      Conserved Domains (1) summary
      cl17037
      Location:5 → 307
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85515.1 GenPept UniProtKB/Swiss-Prot:P85515

    Gene LinkOut

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