Cox15 cytochrome c oxidase assembly homolog COX15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cox15provided by RGD
Full Name: cytochrome c oxidase assembly homolog COX15provided by RGD
Primary source: RGD:1312043
See related: Ensembl:ENSRNOG00000017230 AllianceGenome:RGD:1312043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Predicted to be involved in heme A biosynthetic process and respiratory chain complex IV assembly. Predicted to act upstream of with a positive effect on proton transmembrane transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 2; and hypertrophic cardiomyopathy. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 206.0), Kidney (RPKM 151.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252554811..252571471, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242605588..242622279, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263494850..263511510, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH127403 (e-PCR)
- UniSTS:210713

RH128398 (e-PCR)
- UniSTS:211706

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-CH group of donors	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytochrome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in heme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cytochrome complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COX15 homolog

Names: COX15 cytochrome c oxidase assembly homolog; COX15 homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly homolog 15; cytochrome c oxidase assembly protein COX15 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.