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    PIS1 phosphatidylinositol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843128, updated on 7-Sep-2023

    Summary

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    Gene symbol
    PIS1
    Gene description
    phosphatidylinositol synthase 1
    Primary source
    Araport:AT1G68000
    Locus tag
    AT1G68000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPIS; ATPIS1; PHOSPHATIDYLINOSITOL SYNTHASE; phosphatidylinositol synthase 1; T23K23.15; T23K23_15
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    Genomic context

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    See PIS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (25490911..25493077)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene caffeoyl-CoA 3-O-methyltransferase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene hydroxypyruvate reductase Neighboring gene UDP-Glycosyltransferase / trehalose-phosphatase family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of AtPIS, a phosphatidylinositol synthase from Arabidopsis. Collin S, et al. Eur J Biochem, 1999 Jun. PMID 10411624
    2. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress. Yang Y, et al. Mol Plant, 2021 Dec 6. PMID 34339895
    3. Alternative metabolic fates of phosphatidylinositol produced by phosphatidylinositol synthase isoforms in Arabidopsis thaliana. Löfke C, et al. Biochem J, 2008 Jul 1. PMID 18402553
    4. Cloning of Arabidopsis thaliana phosphatidylinositol synthase and functional expression in the yeast pis mutant. Xue HW, et al. Plant Mol Biol, 2000 Mar. PMID 10809447
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
      Title: Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_105470.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol synthase 1
    NP_176967.1
    • phosphatidylinositol synthase 1 (PIS1); CONTAINS InterPro DOMAIN/s: CDP-alcohol phosphatidyltransferase (InterPro:IPR000462), CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote (InterPro:IPR014387); BEST Arabidopsis thaliana protein match is: probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 (TAIR:AT4G38570.1); Has 2907 Blast hits to 2907 proteins in 1088 species: Archae - 25; Bacteria - 1785; Metazoa - 167; Fungi - 194; Plants - 81; Viruses - 0; Other Eukaryotes - 655 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25490911..25493077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105470.3 → NP_176967.1  phosphatidylinositol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81846, Q8LBA6
      UniProtKB/TrEMBL
      A0A178WC27, A0A5S9WSN1
      Conserved Domains (1) summary
      COG0558
      Location:6 → 126
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LBA6.2

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