Psca prostate stem cell antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pscaprovided by MGI
Official Full Name: prostate stem cell antigenprovided by MGI
Primary source: MGI:MGI:1919623
See related: Ensembl:ENSMUSG00000022598 AllianceGenome:MGI:1919623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210408B04Rik
Summary: Predicted to enable acetylcholine receptor binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and regulation of neurotransmitter receptor activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be anchored component of membrane. Is expressed in alimentary system epithelium; oral cavity; skin; testis; and urinary system. Orthologous to human PSCA (prostate stem cell antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 11209.1) See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74586688..74588914)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74714839..74717065)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17beta-estradiol in C57BL mice
Title: Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17β-estradiol in C57BL mice.
PSCA may play a role in limiting prostate tumor progression in certain contexts, and deletion of PSCA may promote tumor migration and metastasis.
Title: Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.
This transgenic system helps define the range of cellular changes associated with altered expression of PSCA, shows that transcriptional control is a major component regulating PSCA levels.
Title: Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.
Sca-1-enriched prostate-regenerating cells possess multiple stem/progenitor cell properties
Title: The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

Psca (e-PCR), detects polymorphism
- UniSTS:528190

NoName (e-PCR)
- UniSTS:485292

Psca (e-PCR), detects polymorphism
- UniSTS:231354

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostate stem cell antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028216.2 → NP_082492.1 prostate stem cell antigen precursor

See identical proteins and their annotated locations for NP_082492.1

Status: VALIDATED

Source sequence(s)

AF319173, AK008851, EH109693

Consensus CDS

CCDS27526.1

UniProtKB/Swiss-Prot

P57096, Q9D7U0

Related

ENSMUSP00000023265.4, ENSMUST00000023265.5

Conserved Domains (1) summary

cd00117
Location:21 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...