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    Scpep1 serine carboxypeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114861, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Scpep1provided by RGD
    Official Full Name
    serine carboxypeptidase 1provided by RGD
    Primary source
    RGD:620067
    See related
    Ensembl:ENSRNOG00000002358 AllianceGenome:RGD:620067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Risc
    Summary
    Predicted to enable serine-type carboxypeptidase activity. Involved in retinoic acid metabolic process. Located in cytosol. Orthologous to human SCPEP1 (serine carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1236.0), Uterus (RPKM 395.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scpep1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74200491..74230107, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73703275..73732892, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76230371..76263866, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 2 Neighboring gene elongin-B-like Neighboring gene elongin B, pseduogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells. Chen J, et al. J Biol Chem, 2001 Sep 7. PMID 11447226
    2. Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1. Pan X, et al. PLoS Genet, 2014 Feb. PMID 24586188, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type carboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinoic acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinoid-inducible serine carboxypeptidase
    Names
    retinoid-inducible serine caroboxypetidase
    NP_596874.1
    XP_038940969.1
    XP_038940970.1
    XP_063124349.1
    XP_063124350.1
    XP_063124351.1
    XP_063124352.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133383.2 → NP_596874.1  retinoid-inducible serine carboxypeptidase precursor

      See identical proteins and their annotated locations for NP_596874.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q920A6
      UniProtKB/TrEMBL
      A0A8L2Q1H7, A6HHZ2
      Related
      ENSRNOP00000003219.3, ENSRNOT00000003219.4
      Conserved Domains (1) summary
      pfam00450
      Location:36 → 446
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      74200491..74230107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085042.2 → XP_038940970.1  retinoid-inducible serine carboxypeptidase isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q1H7
      Conserved Domains (1) summary
      cl08270
      Location:37 → 369
      Peptidase_S10; Serine carboxypeptidase

    2. XM_063268282.1 → XP_063124352.1  retinoid-inducible serine carboxypeptidase isoform X2

    3. XM_039085041.2 → XP_038940969.1  retinoid-inducible serine carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSM7, A0A8I6AI52
      Related
      ENSRNOP00000092430.1
      Conserved Domains (1) summary
      pfam00450
      Location:46 → 455
      Peptidase_S10; Serine carboxypeptidase

    4. XM_063268279.1 → XP_063124349.1  retinoid-inducible serine carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI52

    5. XM_063268280.1 → XP_063124350.1  retinoid-inducible serine carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI52

    6. XM_063268281.1 → XP_063124351.1  retinoid-inducible serine carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI52
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920A6.1 GenPept UniProtKB/Swiss-Prot:Q920A6

    Gene LinkOut

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