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    Gemin2 gem (nuclear organelle) associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84404, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gemin2provided by RGD
    Official Full Name
    gem (nuclear organelle) associated protein 2provided by RGD
    Primary source
    RGD:620842
    See related
    Ensembl:ENSRNOG00000004360 AllianceGenome:RGD:620842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sip1
    Summary
    Predicted to be involved in negative regulation of RNA binding activity and spliceosomal snRNP assembly. Predicted to be located in Gemini of coiled bodies; cytosol; and nucleolus. Predicted to be part of SMN complex. Predicted to be active in nucleus. Orthologous to human GEMIN2 (gem nuclear organelle associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 99.2), Heart (RPKM 82.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gemin2 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (82442419..82456050)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (76706424..76721154)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (80108751..80122382)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 8 Neighboring gene Sec23 homolog A, COPII coat complex component Neighboring gene high mobility group protein B1-like Neighboring gene cytochrome P450, family 51, subfamily a, polypeptide 1, pseudogene 1 Neighboring gene U2 spliceosomal RNA like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis? Rafałowska J, et al. Folia Neuropathol, 2012. PMID 23319195
    2. Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy. Jablonka S, et al. Hum Mol Genet, 2001 Mar 1. PMID 11181573
    3. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
    4. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Britanova O, et al. Neuron, 2008 Feb 7. PMID 18255031
    5. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Chari A, et al. Cell, 2008 Oct 31. PMID 18984161

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in rat spinal cord neurons, the immunoexpression of SMN and gemins 2 and 4 is present through the whole animal lifespan, are present in the same motoneurons and immunoexpression of gemin 2 and 4 decreases slightly with aging.
      Title: Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the SMN complex a new target in investigations of sporadic amyotrophic lateral sclerosis pathogenesis?
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112609

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Gemini of coiled bodies ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Gemini of coiled bodies ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Sm protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gem-associated protein 2
    Names
    SMN-interacting protein 1
    component of gems 2
    gemin-2
    survival of motor neuron protein-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053389.1 → NP_445841.1  gem-associated protein 2

      See identical proteins and their annotated locations for NP_445841.1

      Status: PROVISIONAL

      Source sequence(s)
      AF176072
      UniProtKB/Swiss-Prot
      Q4G084, Q9QZP1
      Related
      ENSRNOP00000006137.4, ENSRNOT00000006137.6
      Conserved Domains (1) summary
      pfam04938
      Location:22 → 261
      SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      82442419..82456050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113003.2 → XP_038968931.1  gem-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HBQ9
      Conserved Domains (1) summary
      pfam04938
      Location:1 → 139
      SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)

    2. XM_039113002.2 → XP_038968930.1  gem-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HBQ9
      Conserved Domains (1) summary
      pfam04938
      Location:1 → 139
      SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)

    RNA

    1. XR_005505592.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZP1.1 GenPept UniProtKB/Swiss-Prot:Q9QZP1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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