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    Spcs1 signal peptidase complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290555, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spcs1provided by RGD
    Official Full Name
    signal peptidase complex subunit 1provided by RGD
    Primary source
    RGD:1309125
    See related
    AllianceGenome:RGD:1309125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309125
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be part of signal peptidase complex. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 623.3), Kidney (RPKM 536.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spcs1 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6196653..6198221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6190208..6191776, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7080389..7081957, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA SNORD19B Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Host Factor SPCS1 Regulates the Replication of Japanese Encephalitis Virus through Interactions with Transmembrane Domains of NS2B. Ma L, et al. J Virol, 2018 Jun 15. PMID 29593046, Free PMC Article
    2. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. Suzuki R, et al. PLoS Pathog, 2013. PMID 24009510, Free PMC Article
    3. Membrane topology and biogenesis of eukaryotic signal peptidase. Shelness GS, et al. J Biol Chem, 1993 Mar 5. PMID 8444896
    4. Purification of microsomal signal peptidase as a complex. Evans EA, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3511473, Free PMC Article
    5. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188913

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in virion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit 1
    Names
    signal peptidase complex subunit 1 homolog
    NP_001124478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131006.1 → NP_001124478.1  signal peptidase complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      CF976587, CV795143
      Conserved Domains (1) summary
      pfam06645
      Location:12 → 81
      SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6196653..6198221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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