Kars1 lysyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kars1provided by RGD
Official Full Name: lysyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1359653
See related: Ensembl:ENSRNOG00000019456 AllianceGenome:RGD:1359653
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kars; LysRS
Summary: Enables several functions, including ATP binding activity; lysine-tRNA ligase activity; and tRNA binding activity. Involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Located in cytosol and nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 543.7), Heart (RPKM 483.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (56867096..56886151, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (39957846..39976837, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (44212205..44231209, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP:ADP adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP:ADP adenylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ATP:ADP adenylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables lysine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in basophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in basophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basophil activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in diadenosine tetraphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine tetraphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diadenosine tetraphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diadenosine tetraphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lysyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in lysyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in lysyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysine--tRNA ligase

NP_001006968.1

EC 6.1.1.6

NP_001386122.1

EC 6.1.1.6

XP_063134012.1

EC 6.1.1.6

XP_063134013.1

EC 6.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.