Mrm2 mitochondrial rRNA methyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrm2provided by RGD
Official Full Name: mitochondrial rRNA methyltransferase 2provided by RGD
Primary source: RGD:1305944
See related: Ensembl:ENSRNOG00000043267 AllianceGenome:RGD:1305944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ftsj2
Summary: Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to be located in nucleolus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 39.6), Muscle (RPKM 28.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (19423448..19428662)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (14309556..14314759)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (16398749..16403656)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables rRNA (uridine-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial large ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rRNA methyltransferase 2, mitochondrial

Names: FtsJ RNA methyltransferase homolog 2; FtsJ homolog 2; putative ribosomal RNA methyltransferase 2

NP_001100595.1

EC 2.1.1.-

XP_038945316.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107125.1 → NP_001100595.1 rRNA methyltransferase 2, mitochondrial

See identical proteins and their annotated locations for NP_001100595.1

Status: PROVISIONAL

Source sequence(s)

CH474012

UniProtKB/TrEMBL

A6K1T1, D3ZGI8

Related

ENSRNOP00000050915.3, ENSRNOT00000042366.4

Conserved Domains (1) summary

COG0293
Location:33 → 241

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

19423448..19428662

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089388.2 → XP_038945316.1 rRNA methyltransferase 2, mitochondrial isoform X1

Conserved Domains (1) summary

COG0293
Location:1 → 206

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]