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    Dtwd1 DTW domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296119, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Dtwd1provided by RGD
    Official Full Name
    DTW domain containing 1provided by RGD
    Primary source
    RGD:1311144
    See related
    Ensembl:ENSRNOG00000009593 AllianceGenome:RGD:1311144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311144
    Summary
    Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be active in nucleus. Orthologous to human DTWD1 (DTW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 23.0), Testes (RPKM 22.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtwd1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133845768..133859965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113392402..113409322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118427790..118443003)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biogenesis and functions of aminocarboxypropyluridine in tRNA. Takakura M, et al. Nat Commun, 2019 Dec 5. PMID 31804502, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA-uridine aminocarboxypropyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-uridine aminocarboxypropyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-uridine aminocarboxypropyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-uridine aminocarboxypropyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-uridine aminocarboxypropyltransferase 1
    Names
    DTW domain-containing protein 1
    NP_001013943.2
    NP_001380702.1
    XP_006234976.1
    XP_017447067.1
    XP_038960493.1
    XP_063139395.1
    XP_063139396.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013921.2 → NP_001013943.2  tRNA-uridine aminocarboxypropyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AYF5

    2. NM_001393773.1 → NP_001380702.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AYF5

    3. NM_001430097.1 → NP_001417026.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AYF5
      UniProtKB/TrEMBL
      A6HPY2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      133845768..133859965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234914.5 → XP_006234976.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam03942
      Location:81 → 304
      DTW; DTW domain

    2. XM_063283325.1 → XP_063139395.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

    3. XM_063283326.1 → XP_063139396.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X4

    4. XM_039104565.2 → XP_038960493.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6AYF5
      UniProtKB/TrEMBL
      A6HPY2
      Related
      ENSRNOP00000012966.4
      Conserved Domains (1) summary
      pfam03942
      Location:81 → 304
      DTW; DTW domain

    5. XM_017591578.3 → XP_017447067.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZV5, F1M7Q4
      Related
      ENSRNOP00000085303.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYF5.1 GenPept UniProtKB/Swiss-Prot:Q6AYF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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