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    Tom1l2 target of myb1 like 2 membrane trafficking protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360537, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tom1l2provided by RGD
    Official Full Name
    target of myb1 like 2 membrane trafficking proteinprovided by RGD
    Primary source
    RGD:1306728
    See related
    Ensembl:ENSRNOG00000003590 AllianceGenome:RGD:1306728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable clathrin binding activity and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division and signal transduction. Predicted to be active in endosome and membrane. Orthologous to human TOM1L2 (target of myb1 like 2 membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 150.9), Brain (RPKM 142.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tom1l2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45535548..45657528, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45036034..45158168, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46599392..46720921, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549418 Neighboring gene retinoic acid induced 1 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene GID complex subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Franco M, et al. Mol Cell Biol, 2006 Mar. PMID 16479011, Free PMC Article
    2. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Katoh Y, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16412388
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TOM1-like protein 2
    Names
    target of myb1-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399549.1 → NP_001386478.1  TOM1-like protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000096987.1, ENSRNOT00000101854.1

    2. NM_001399550.1 → NP_001386479.1  TOM1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZT36
      Related
      ENSRNOP00000081923.1, ENSRNOT00000106889.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45535548..45657528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246508.5 → XP_006246570.1  TOM1-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1X4, A0A8I6AVU7
      Related
      ENSRNOP00000086296.1
      Conserved Domains (2) summary
      cd03565
      Location:12 → 152
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14238
      Location:218 → 309
      GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

    2. XM_006246506.5 → XP_006246568.1  TOM1-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZP70, A0A8I6AVU7
      Related
      ENSRNOP00000080247.1
      Conserved Domains (2) summary
      cd03565
      Location:12 → 152
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14238
      Location:218 → 309
      GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

    3. XM_039086309.2 → XP_038942237.2  TOM1-like protein 2 isoform X1

    4. XM_008767835.4 → XP_008766057.2  TOM1-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AVU7
      Conserved Domains (2) summary
      cd14238
      Location:185 → 276
      GAT_TM1L2; canonical GAT domain found in target of Myb-like protein 2 (Tom1L2)
      cl02544
      Location:1 → 115
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily

    5. XM_063269332.1 → XP_063125402.1  TOM1-like protein 2 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108277.1: Suppressed sequence

      Description
      NM_001108277.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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