Ptprv protein tyrosine phosphatase, receptor type, V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprvprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Vprovided by RGD
Primary source: RGD:621123
See related: Ensembl:ENSRNOG00000005277 AllianceGenome:RGD:621123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Esp
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in bone remodeling. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 77.4), Uterus (RPKM 24.6) and 3 other tissues See more
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Genomic context

Location:: 13q13

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49099922..49120247, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46548125..46569148, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51935239..51956262, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in bone remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoclast development	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase V

Names: ES cell phosphatase; OST-PTP; Osteotesticular phosphatase; R-PTP-V; embryonic stem cell protein-tyrosine phosphatase; osteotesticular protein-tyrosine phosphatase; protein tyrosine phosphatase receptor type W

NP_149090.1

EC 3.1.3.48

XP_038946996.1

EC 3.1.3.48

XP_038946997.1

EC 3.1.3.48

XP_038946998.1

EC 3.1.3.48

XP_038946999.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033099.1 → NP_149090.1 receptor-type tyrosine-protein phosphatase V precursor

See identical proteins and their annotated locations for NP_149090.1

Status: PROVISIONAL

Source sequence(s)

L36884

UniProtKB/Swiss-Prot

Q64612

UniProtKB/TrEMBL

A0A8I6AM78

Related

ENSRNOP00000007597.3, ENSRNOT00000007597.6

Conserved Domains (6) summary

smart00060
Location:473 → 547

FN3; Fibronectin type 3 domain

smart00194
Location:1150 → 1408

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1177 → 1408

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:656 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:131 → 201

fn3; Fibronectin type III domain

cl21483
Location:1521 → 1693

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

49099922..49120247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091070.2 → XP_038946998.1 receptor-type tyrosine-protein phosphatase V isoform X3

UniProtKB/TrEMBL

A0A8I6AM78

Conserved Domains (6) summary

smart00060
Location:473 → 547

FN3; Fibronectin type 3 domain

cd00063
Location:656 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14618
Location:1120 → 1349

R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V

pfam00041
Location:148 → 201

fn3; Fibronectin type III domain

pfam18861
Location:950 → 1044

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl28904
Location:1419 → 1635

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039091068.2 → XP_038946996.1 receptor-type tyrosine-protein phosphatase V isoform X1

UniProtKB/TrEMBL

A0A8I6AM78, F1M8J3

Conserved Domains (6) summary

smart00060
Location:473 → 547

FN3; Fibronectin type 3 domain

cd00063
Location:656 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14618
Location:1178 → 1407

R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V

pfam00041
Location:148 → 201

fn3; Fibronectin type III domain

pfam18861
Location:950 → 1102

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl28904
Location:1477 → 1693

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039091069.2 → XP_038946997.1 receptor-type tyrosine-protein phosphatase V isoform X2

UniProtKB/TrEMBL

A0A8I6AM78

Conserved Domains (5) summary

smart00060
Location:432 → 506

FN3; Fibronectin type 3 domain

cd00063
Location:615 → 684

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:107 → 160

fn3; Fibronectin type III domain

pfam18861
Location:909 → 1061

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl28904
Location:1137 → 1366

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039091071.2 → XP_038946999.1 receptor-type tyrosine-protein phosphatase V isoform X4

UniProtKB/TrEMBL

A6ICD7

Conserved Domains (5) summary

smart00060
Location:473 → 547

FN3; Fibronectin type 3 domain

cd00063
Location:656 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:148 → 201

fn3; Fibronectin type III domain

pfam18861
Location:950 → 1102

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl28904
Location:1178 → 1351

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily