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    Med15 mediator complex subunit 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360743, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Med15provided by RGD
    Official Full Name
    mediator complex subunit 15provided by RGD
    Primary source
    RGD:1307560
    See related
    Ensembl:ENSRNOG00000001877 AllianceGenome:RGD:1307560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcqap
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of mediator complex. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 97.8), Spleen (RPKM 95.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med15 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96784974..96859635)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83280722..83356006)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87553868..87628631, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 22 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene ribosomal protein S15, pseudogene 13 Neighboring gene ribosomal protein L34, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 74A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. De Luca A, et al. Am J Med Genet B Neuropsychiatr Genet, 2003 Jan 1. PMID 12497610
    2. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    3. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 15
    Names
    positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108325.1 → NP_001101795.1  mediator of RNA polymerase II transcription subunit 15

      See identical proteins and their annotated locations for NP_001101795.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A0A8I5ZVE0, A6JSK4, G3V684
      Related
      ENSRNOP00000002568.4, ENSRNOT00000002568.6
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 786
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96784974..96859635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088530.2 → XP_038944458.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVE0
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 715
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. XM_006248702.5 → XP_006248764.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A373, A0A8I6GJV4
      Related
      ENSRNOP00000085424.1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 746
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. XM_063270660.1 → XP_063126730.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    4. XM_063270659.1 → XP_063126729.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    5. XM_006248706.5 → XP_006248768.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZVE0
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 763
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    6. XM_039088531.2 → XP_038944459.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJV4
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 703
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    7. XM_039088532.2 → XP_038944460.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVE0
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 675
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    8. XM_039088533.2 → XP_038944461.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJV4
      Conserved Domains (1) summary
      pfam09606
      Location:344 → 632
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein Strain
    Heading Accession and Version

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