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    Clptm1l CLPTM1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316916, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Clptm1lprovided by RGD
    Official Full Name
    CLPTM1-likeprovided by RGD
    Primary source
    RGD:1307896
    See related
    Ensembl:ENSRNOG00000016923 AllianceGenome:RGD:1307896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307896
    Summary
    Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human CLPTM1L (CLPTM1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 159.7), Kidney (RPKM 134.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clptm1l in Genome Data Viewer
    Location:
    1p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31496094..31512148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29667545..29683530, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32281207..32297196, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II transcriptional coactivator-like Neighboring gene telomerase reverse transcriptase Neighboring gene uncharacterized LOC134484979 Neighboring gene solute carrier family 6 member 3 Neighboring gene lysophosphatidylcholine acyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evaluation of Rare and Common Variants from Suspected Familial or Sporadic Nasopharyngeal Carcinoma (NPC) Susceptibility Genes in Sporadic NPC. Liu Z, et al. Cancer Epidemiol Biomarkers Prev, 2019 Oct. PMID 31270100, Free PMC Article
    2. TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma. Lee HW, et al. Onco Targets Ther, 2017. PMID 29042796, Free PMC Article
    3. CLPTM1L polymorphism as a protective factor for lung cancer: a case-control study in southern Chinese population. Jin T, et al. Tumour Biol, 2016 Aug. PMID 26852039
    4. CLPTM1L genetic polymorphisms and interaction with smoking and alcohol drinking in lung cancer risk: a case-control study in the Han population from northwest China. Xun X, et al. Medicine (Baltimore), 2014 Dec. PMID 25526467, Free PMC Article
    5. A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC). Azad AK, et al. Lung Cancer, 2014 Jun. PMID 24679952

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipid scramblase CLPTM1L
    Names
    cleft lip and palate transmembrane protein 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108240.1 → NP_001101710.1  lipid scramblase CLPTM1L

      See identical proteins and their annotated locations for NP_001101710.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474002
      UniProtKB/TrEMBL
      A0A8I6AWZ9, A6JUX5, D4A416
      Related
      ENSRNOP00000023211.5, ENSRNOT00000023211.6
      Conserved Domains (1) summary
      pfam05602
      Location:22 → 423
      CLPTM1; Cleft lip and palate transmembrane protein 1 (CLPTM1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31496094..31512148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227791.5 → XP_006227853.1  lipid scramblase CLPTM1L isoform X1

      UniProtKB/TrEMBL
      A0A8I6AWZ9
      Conserved Domains (1) summary
      pfam05602
      Location:22 → 421
      CLPTM1; Cleft lip and palate transmembrane protein 1 (CLPTM1)
    Nucleotide Protein Strain
    Heading Accession and Version

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