Gnl3 G protein nucleolar 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnl3provided by RGD
Official Full Name: G protein nucleolar 3provided by RGD
Primary source: RGD:631354
See related: Ensembl:ENSRNOG00000028461 AllianceGenome:RGD:631354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ns
Summary: Enables GTP binding activity. Involved in cell population proliferation and regulation of cell population proliferation. Located in nucleolus. Orthologous to human GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 258.6), Spleen (RPKM 225.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6213844..6220029, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6207402..6213491, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7097580..7103518, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma.
Title: Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma.
In summary, this report suggested that Nucleostemin may exert the anti-apoptotic effect through Nucleostemin-p53 signaling pathway after myocardial reperfusion injury.
Title: Nucleostemin exerts anti-apoptotic function via p53 signaling pathway in cardiomyocytes.
Nucleostemin expression in cardiomyocytes is induced by fibroblast growth factor-2 and accumulates in response to Pim-1 kinase activity.
Title: Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge.
cell cycle arrest/inhibitory role of nucleostemin is unlikely to be related to its proposed property of interaction with p53
Title: Knocking-down the expression of nucleostemin significantly decreases rate of proliferation of rat bone marrow stromal stem cells in an apparently p53-independent manner.
Results suggest that nucleostemin, but not Oct-4 or Nanog, is expressed in bone marrow stromal cells where it possibly regulates self-renewal cell proliferation.
Title: Nucleostemin, a coordinator of self-renewal, is expressed in rat marrow stromal cells and turns off after induction of neural differentiation.
analysis of nucleolar localization of stem cell protein nucleostemin
Title: A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell division	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein-like 3

Names: guanine nucleotide binding protein-like 3 (nucleolar); nucleolar GTP-binding protein 3; nucleostemin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175580.3 → NP_783170.1 guanine nucleotide-binding protein-like 3

See identical proteins and their annotated locations for NP_783170.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q566E0, Q811S9

UniProtKB/TrEMBL

A6KG10, A6KG11

Related

ENSRNOP00000035860.3, ENSRNOT00000033677.6

Conserved Domains (3) summary

cd04178
Location:140 → 302

Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

COG1161
Location:125 → 420

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

pfam08701
Location:16 → 93

GN3L_Grn1; GNL3L/Grn1 putative GTPase