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    Nfu1 NFU1 iron-sulfur cluster scaffold [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297416, updated on 6-Jun-2024

    Summary

    Official Symbol
    Nfu1provided by RGD
    Official Full Name
    NFU1 iron-sulfur cluster scaffoldprovided by RGD
    Primary source
    RGD:1307823
    See related
    Ensembl:ENSRNOG00000018410 AllianceGenome:RGD:1307823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hirip5
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 150.5), Muscle (RPKM 128.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nfu1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121016316..121036925)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119458981..119480162)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118814284..118834955)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene uncharacterized LOC134486608 Neighboring gene uncharacterized LOC120102328 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Names
    histone cell cycle regulation defective interacting protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106606.2NP_001100076.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001100076.2

      Status: VALIDATED

      Source sequence(s)
      FM058785, FM064033, FM092780
      UniProtKB/TrEMBL
      A6IAZ7, D3ZA85
      Related
      ENSRNOP00000024884.6, ENSRNOT00000024884.7
      Conserved Domains (2) summary
      smart00932
      Location:59146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:171237
      NifU; NifU-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121016316..121036925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285813.1XP_063141883.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      D3ZA85
    2. XM_063285814.1XP_063141884.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

    3. XM_039107363.2XP_038963291.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

      Conserved Domains (2) summary
      pfam01106
      Location:81147
      NifU; NifU-like domain
      cl07364
      Location:3356
      Nfu_N; Scaffold protein Nfu/NifU N terminal
    4. XM_063285815.1XP_063141885.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3