Pxk PX domain containing serine/threonine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pxkprovided by RGD
Official Full Name: PX domain containing serine/threonine kinaseprovided by RGD
Primary source: RGD:727819
See related: Ensembl:ENSRNOG00000008024 AllianceGenome:RGD:727819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including inflammatory response; modulation of chemical synaptic transmission; and negative regulation of ATPase activity. Predicted to be located in centriolar satellite; cytosol; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 79.5), Kidney (RPKM 78.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (19190085..19258711, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (16759857..16828452, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (18548209..18616617, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI297004 (e-PCR)
- UniSTS:248099

RH137973 (e-PCR)
- UniSTS:220060

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ATP-dependent activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of monoatomic ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PX domain-containing protein kinase-like protein

Names: MONaKA; PX serine/threonine kinase; modulator of Na,K-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399677.1 → NP_001386606.1 PX domain-containing protein kinase-like protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q4FZZ1, Q7TNZ7

Related

ENSRNOP00000010763.6, ENSRNOT00000010763.7
NM_182821.2 → NP_877973.1 PX domain-containing protein kinase-like protein isoform 1

See identical proteins and their annotated locations for NP_877973.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A140TAA2, A0A8I5ZY08

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

19190085..19258711 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599722.2 → XP_017455211.1 PX domain-containing protein kinase-like protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZY08
XM_063274363.1 → XP_063130433.1 PX domain-containing protein kinase-like protein isoform X3
XM_063274362.1 → XP_063130432.1 PX domain-containing protein kinase-like protein isoform X2
XM_008770539.4 → XP_008768761.1 PX domain-containing protein kinase-like protein isoform X9

UniProtKB/TrEMBL

A6K0B8

Conserved Domains (1) summary

cd00180
Location:61 → 208

PKc; Catalytic domain of Protein Kinases
XM_039093421.2 → XP_038949349.1 PX domain-containing protein kinase-like protein isoform X11

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cl21453
Location:198 → 345

PKc_like; Protein Kinases, catalytic domain
XM_063274365.1 → XP_063130435.1 PX domain-containing protein kinase-like protein isoform X10
XM_017599727.2 → XP_017455216.1 PX domain-containing protein kinase-like protein isoform X8
XM_017599725.3 → XP_017455214.1 PX domain-containing protein kinase-like protein isoform X6
XM_017599726.3 → XP_017455215.1 PX domain-containing protein kinase-like protein isoform X7
XM_006251776.5 → XP_006251838.1 PX domain-containing protein kinase-like protein isoform X5

UniProtKB/TrEMBL

A0A8I6G486

Related

ENSRNOP00000080198.1

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_017599723.3 → XP_017455212.1 PX domain-containing protein kinase-like protein isoform X4