Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r2provided by RGD
Official Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 2provided by RGD
Primary source: RGD:621099
See related: Ensembl:ENSRNOG00000001733 AllianceGenome:RGD:621099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IPP-2
Summary: Enables protein domain specific binding activity. Involved in negative regulation of protein binding activity. Located in cytoplasm; dendritic spine; and growth cone. Orthologous to several human genes including PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905933.1 and NW_007905934.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
Expression: Biased expression in Muscle (RPKM 634.8), Heart (RPKM 449.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (82977634..82999426)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (69472676..69494468)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (72748789..73034683)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel calcium-induced IPP-2 activation pathway is found that is critical for homeostatic synaptic plasticity.
Title: An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.

Submit: New GeneRIF Correction

General gene information

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Markers

D16Mit229 (e-PCR), detects polymorphism
- UniSTS:127863

AA858773 (e-PCR)
- UniSTS:243423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase inhibitor 2

Names: phosphatase inhibitor 2; protein phosphatase 1, regulatory subunit 2

NP_620178.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.