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    Gucy2g guanylate cyclase 2G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245708, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Gucy2gprovided by RGD
    Official Full Name
    guanylate cyclase 2Gprovided by RGD
    Primary source
    RGD:621853
    See related
    Ensembl:ENSRNOG00000015724 AllianceGenome:RGD:621853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ksGC
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 13.9), Kidney (RPKM 5.8) and 1 other tissue See more
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    Genomic context

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    See Gucy2g in Genome Data Viewer
    Location:
    1q55
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264241830..264285615, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254237778..254280277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276187243..276228574, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553657 Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression. Kojima M, et al. Biochem Biophys Res Commun, 1995 Dec 26. PMID 8554626
    2. The cloning and expression of a new guanylyl cyclase orphan receptor. Schulz S, et al. J Biol Chem, 1998 Jan 9. PMID 9422765
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate cyclase 2G
    Names
    GC-G
    guanylyl cyclase receptor G
    guanylyl cyclase with kinase-like domain, soluble
    kinase-like domain-containing soluble guanylyl cyclase
    NP_620611.2
    XP_038953385.1
    XP_038953425.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139042.2 → NP_620611.2  guanylate cyclase 2G

      See identical proteins and their annotated locations for NP_620611.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O54884, P55205
      UniProtKB/TrEMBL
      A6JHY5, F1MA14
      Related
      ENSRNOP00000021744.4, ENSRNOT00000021746.6
      Conserved Domains (5) summary
      cd06372
      Location:50 → 439
      PBP1_GC_G_like; Ligand-binding domain of membrane guanylyl cyclase G
      smart00044
      Location:868 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd13992
      Location:558 → 832
      PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
      pfam00211
      Location:895 → 1081
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:66 → 417
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      264241830..264285615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097457.2 → XP_038953385.1  guanylate cyclase 2G isoform X1

      UniProtKB/TrEMBL
      A6JHY7
      Conserved Domains (2) summary
      smart00044
      Location:199 → 389
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:1 → 163
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039097497.2 → XP_038953425.1  guanylate cyclase 2G isoform X1

      UniProtKB/TrEMBL
      A6JHY7
      Conserved Domains (2) summary
      smart00044
      Location:199 → 389
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:1 → 163
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55205.2 GenPept UniProtKB/Swiss-Prot:P55205

    Gene LinkOut

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