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Ptger4 prostaglandin E receptor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84023, updated on 2-May-2024

Summary

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Official Symbol: Ptger4provided by RGD
Official Full Name: prostaglandin E receptor 4provided by RGD
Primary source: RGD:628641
See related: Ensembl:ENSRNOG00000013240 AllianceGenome:RGD:628641
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EP4; Ptger; Ptgerep4
Summary: Enables prostaglandin E receptor activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; regulation of cytokine production; and regulation of secretion. Located in several cellular components, including neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 55.1), Spleen (RPKM 41.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Ptger4 in Genome Data Viewer

Location:: 2q16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (56061699..56074594, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (54330563..54347451, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (54951625..54966470, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Title: Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Title: Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Title: Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with amplification by IL-1beta and the EP4 receptor.
Title: A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor.
This work has generated a set of novel homology models of the rEP4 and hEP4 receptors.
Title: Improved homology modeling of the human & rat EP(4) prostanoid receptors.
We found that rats injected with the 30mug dose of PGE2 exhibited the most pronounced thermal nociceptive hypersensitivity though secondary analysis showed that rats injected with PGE2 doses of 0.03-30mug had lower withdrawal latencies as compared to rats injected with vehicle.
Title: A dose response study of the effect of prostaglandin E2 on thermal nociceptive sensitivity.
Data suggest that EP4 recycling contributes to agonist-induced cell surface abundance and consequently enhanced receptor sensitivity. Facilitating EP4 externalization and recycling is a novel mechanism underlying PGE2-induced nociceptor sensitization.
Title: Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity.
PGE2 uses different receptors and mechanisms to ultimately decrease MMP expression and fibroblast migration.
Title: PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
These studies demonstrate, for the first time, that BBR exerts renoprotective effects in different stages of DN via EP4- Galphas- AC-cAMP signaling pathway in STZ-induced DN rats fed a high-sugar and high-fat diet.
Title: The renoprotective effects of berberine via the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats.
Our findings identify vascular PGE2 signaling through its EP4 receptor as protective in hypoxic-ischemic encephalopathy.
Title: Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.

Submit: New GeneRIF Correction See all GeneRIFs (36)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin E receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in T-helper cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone development	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prostaglandin E stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ductus arteriosus closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ductus arteriosus closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eosinophil extravasation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of eosinophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric-oxide synthase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of small intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antral ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcitonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hyaluronan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of matrix metallopeptidase secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substance P secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substance P secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to prostaglandin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water-immersion restraint stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP4 subtype

Names: PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor type 4; prostanoid EP4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032076.3 → NP_114465.3 prostaglandin E2 receptor EP4 subtype

See identical proteins and their annotated locations for NP_114465.3

Status: PROVISIONAL

Source sequence(s)

U94709

UniProtKB/Swiss-Prot

O08728, P43114

UniProtKB/TrEMBL

A0A0G2JSM6, A6KGE5

Conserved Domains (1) summary

cd15142
Location:18 → 344

7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

56061699..56074594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103261.2 → XP_038959189.1 prostaglandin E2 receptor EP4 subtype isoform X1

UniProtKB/Swiss-Prot

O08728, P43114

UniProtKB/TrEMBL

A0A0G2JSM6, A6KGE5

Conserved Domains (1) summary

cd15142
Location:18 → 344

7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006231996.5 → XP_006232058.1 prostaglandin E2 receptor EP4 subtype isoform X1

See identical proteins and their annotated locations for XP_006232058.1

UniProtKB/Swiss-Prot

O08728, P43114

UniProtKB/TrEMBL

A0A0G2JSM6, A6KGE5

Related

ENSRNOP00000017886.3

Conserved Domains (1) summary

cd15142
Location:18 → 344

7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors