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    Gpr155 G protein-coupled receptor 155 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311730, updated on 5-Mar-2024

    Summary

    Official Symbol
    Gpr155provided by RGD
    Official Full Name
    G protein-coupled receptor 155provided by RGD
    Primary source
    RGD:1309162
    See related
    Ensembl:ENSRNOG00000018485 AllianceGenome:RGD:1309162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cognition. Predicted to be integral component of membrane. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 90.4), Muscle (RPKM 51.5) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gpr155 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78623931..78677803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58216422..58270350, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60051545..60105567, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene secernin 3 Neighboring gene uncharacterized LOC134486289 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene uncharacterized LOC134486113

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysosomal cholesterol signaling protein
    Names
    integral membrane protein GPR155

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107811.1NP_001101281.1  lysosomal cholesterol signaling protein

      See identical proteins and their annotated locations for NP_001101281.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A0G2JZP1, A6HM90, D3ZWM3
      Related
      ENSRNOP00000025158.4, ENSRNOT00000025158.6
      Conserved Domains (3) summary
      cd04443
      Location:749831
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl21561
      Location:387507
      7tm_4; Olfactory receptor
      cl22894
      Location:36364
      Mem_trans; Membrane transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78623931..78677803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234356.5XP_006234418.1  lysosomal cholesterol signaling protein isoform X2

      UniProtKB/TrEMBL
      A6HM92
      Conserved Domains (3) summary
      cl02442
      Location:749776
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl21561
      Location:387507
      7tm_4; Olfactory receptor
      cl22894
      Location:36364
      Mem_trans; Membrane transport protein
    2. XM_039105161.2XP_038961089.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/TrEMBL
      A6HM92
      Conserved Domains (4) summary
      cl22894
      Location:36364
      Mem_trans; Membrane transport protein
      cd14964
      Location:410432
      7tm_GPCRs; TM helix 2 [structural motif]
      cl02442
      Location:749773
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl28897
      Location:385507
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006234357.5XP_006234419.1  lysosomal cholesterol signaling protein isoform X3

      See identical proteins and their annotated locations for XP_006234419.1

      UniProtKB/TrEMBL
      A6HM91, A6HM92
      Conserved Domains (3) summary
      cl02442
      Location:749777
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl21561
      Location:387507
      7tm_4; Olfactory receptor
      cl22894
      Location:36364
      Mem_trans; Membrane transport protein