Lama1 laminin subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lama1provided by RGD
Official Full Name: laminin subunit alpha 1provided by RGD
Primary source: RGD:1307207
See related: Ensembl:ENSRNOG00000017237 AllianceGenome:RGD:1307207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glycosphingolipid binding activity and protein C-terminus binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including animal organ development; axon guidance; and protein phosphorylation. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Predicted to be located in several cellular components, including cell-cell junction; extracellular matrix; and extracellular space. Predicted to be part of laminin-1 complex and laminin-3 complex. Predicted to be active in basement membrane. Orthologous to human LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 58.5), Testes (RPKM 35.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 63

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (115139548..115263620)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (107692770..107816847)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (115916907..116042123)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data confirmed aquaporin-4 and laminin-alpha1 induction in cMVs.
Title: Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-Hyperlipidemic, Dahl salt-sensitive hypertensive rats.
Findings demonstrate the interdependence between laminin binding to dystroglycan and GM1-containing lipid raft reorganization and provide novel insight into the dystrophin complex regulation of AQP4 polarization in astrocytes.
Title: Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes.
The aim of this study was to investigate the immunohistochemical distribution of laminin, vimentin and desmin during the implantation period in the rat.
Title: Distribution of laminin, vimentin and desmin in the rat uterus during initial stages of implantation.

Submit: New GeneRIF Correction

General gene information

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Markers

AU027041 (e-PCR)
- UniSTS:113688

RH128223 (e-PCR)
- UniSTS:211531

Lama1 (e-PCR), detects polymorphism
- UniSTS:256619

BF401259 (e-PCR)
- UniSTS:245448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables glycosphingolipid binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in blood vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of laminin complex	ISO Inferred from Sequence Orthology more info
part_of laminin-1 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-3 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit alpha-1

Names: laminin, alpha 1; laminin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108237.3 → NP_001101707.2 laminin subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_001101707.2

Status: VALIDATED

Source sequence(s)

BE108973, JAXUCZ010000009

UniProtKB/TrEMBL

D4A409, E3W9F8

Related

ENSRNOP00000023224.5, ENSRNOT00000023226.7

Conserved Domains (10) summary

smart00136
Location:25 → 275

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:715 → 739

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:748 → 796

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2314 → 2470

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00052
Location:575 → 703

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:909 → 955

Laminin_EGF; Laminin EGF domain

pfam00054
Location:2751 → 2880

Laminin_G_1; Laminin G domain

pfam06008
Location:1574 → 1825

Laminin_I; Laminin Domain I

pfam06009
Location:2018 → 2152

Laminin_II; Laminin Domain II

cl02488
Location:1613 → 1861

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

115139548..115263620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083800.2 → XP_038939728.1 laminin subunit alpha-1 isoform X1

Conserved Domains (5) summary

smart00136
Location:25 → 275

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:572 → 702

LamB; Laminin B domain

cd00055
Location:748 → 796

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00052
Location:1225 → 1367

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:909 → 955

Laminin_EGF; Laminin EGF domain