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    Hist1h2ao histone cluster 1, H2ao [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364723, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Hist1h2aoprovided by RGD
    Official Full Name
    histone cluster 1, H2aoprovided by RGD
    Primary source
    RGD:1304905
    See related
    AllianceGenome:RGD:1304905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to be involved in DNA-templated transcription, initiation; cell differentiation; and ossification. Predicted to be located in nucleoplasm. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Hist1h2ao in Genome Data Viewer
    Location:
    17p11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (47400488..47400878, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (42704740..42705130, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (44744534..44744931, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene histone H2A type 1-like Neighboring gene histone cluster 1, H4m Neighboring gene uracil-DNA glycosylase, pseudogene 1 Neighboring gene histone cluster 1 H2A family like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure and microheterogeneities of rat chloroleukemia histone H2A (histone ALK, IIbl or F2a2). Laine B, et al. Biochemistry, 1976 Apr 20. PMID 1268188
    2. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mitra P, et al. Mol Cell Biol, 2003 Nov. PMID 14585971, Free PMC Article
    3. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Sims JK, et al. Mol Cell Biol, 2008 Jul. PMID 18474616, Free PMC Article
    4. Structure of human nucleosome containing the testis-specific histone variant TSH2B. Urahama T, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699735, Free PMC Article
    5. Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. Zhai N, et al. J Mol Cell Biol, 2012 Aug. PMID 22368283

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    histone H2A type 1-E
    Names
    histone 1, H2ao

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408759.1 → NP_001395688.1  histone H2A type 1-E

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P62804, Q5BM23, Q7M0E8
      UniProtKB/TrEMBL
      A6KLQ0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      47400488..47400878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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