Fer FER tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ferprovided by RGD
Official Full Name: FER tyrosine kinaseprovided by RGD
Primary source: RGD:1306273
See related: Ensembl:ENSRNOG00000015898 AllianceGenome:RGD:1306273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Flk; Fert2; Flk_retired
Summary: Enables several functions, including cadherin binding activity; enzyme binding activity; and gamma-catenin binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of mast cell activation involved in immune response. Predicted to act upstream of or within protein autophosphorylation and signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 44.5), Kidney (RPKM 42.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (110967317..111274315)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (103520452..103827364)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (111557804..111868583)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics.
Title: Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.
Results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function.
Title: Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.
Fer kinase structurally associates with the N-cadherin/catenin protein complex in the testis and can possibly be used to mediate signaling function via the cadherin/catenin protein complex [Fer tyrosine kinase]
Title: Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study.

Submit: New GeneRIF Correction

General gene information

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Markers

d9rat140 (e-PCR)
- UniSTS:122510

AI010628 (e-PCR)
- UniSTS:250013

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fc-epsilon receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc-epsilon receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Kit signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Kit signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Sertoli cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adherens junction assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in adherens junction disassembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in diapedesis	ISO Inferred from Sequence Orthology more info
involved_in diapedesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mast cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to platelet-derived growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to platelet-derived growth factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in seminiferous tubule development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Fer

Names: c-FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; p94-FER; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; tyrosine protein kinase FLK

NP_001100398.1

EC 2.7.10.2

NP_001382687.1

EC 2.7.10.2

XP_008765589.1

EC 2.7.10.2

XP_038939361.1

EC 2.7.10.2

XP_038939364.1

EC 2.7.10.2

XP_038939366.1

EC 2.7.10.2

XP_038939367.1

EC 2.7.10.2

XP_038939368.1

EC 2.7.10.2

XP_038939369.1

EC 2.7.10.2

XP_038939370.1

EC 2.7.10.2

XP_038939371.1

EC 2.7.10.2

XP_038939372.1

EC 2.7.10.2

XP_038939373.1

EC 2.7.10.2

XP_038939374.1

EC 2.7.10.2

XP_038939375.1

EC 2.7.10.2

XP_038939376.1

EC 2.7.10.2

XP_063123116.1

EC 2.7.10.2

XP_063123117.1

EC 2.7.10.2

XP_063123118.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106928.1 → NP_001100398.1 tyrosine-protein kinase Fer isoform 1

See identical proteins and their annotated locations for NP_001100398.1

Status: VALIDATED

Source sequence(s)

CH473997

UniProtKB/TrEMBL

A6JRA6

Related

ENSRNOP00000053268.2, ENSRNOT00000056430.3

Conserved Domains (3) summary

cd10361
Location:84 → 169

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:194 → 445

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:197 → 447

PKc_like; Protein Kinases, catalytic domain
NM_001395758.1 → NP_001382687.1 tyrosine-protein kinase Fer isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

F1MA12, P09760

UniProtKB/TrEMBL

A0A140TAC4

Related

ENSRNOP00000090379.1, ENSRNOT00000097737.1

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

110967317..111274315

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083433.2 → XP_038939361.1 tyrosine-protein kinase Fer isoform X2

UniProtKB/TrEMBL

A0A140TAC4

Related

ENSRNOP00000021758.6

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:566 → 816

PKc_like; Protein Kinases, catalytic domain
XM_063267046.1 → XP_063123116.1 tyrosine-protein kinase Fer isoform X3
XM_063267047.1 → XP_063123117.1 tyrosine-protein kinase Fer isoform X5
XM_039083447.2 → XP_038939375.1 tyrosine-protein kinase Fer isoform X10

Conserved Domains (1) summary

cl12013
Location:5 → 238

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039083448.2 → XP_038939376.1 tyrosine-protein kinase Fer isoform X11

Conserved Domains (1) summary

cl12013
Location:5 → 238

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039083446.2 → XP_038939374.1 tyrosine-protein kinase Fer isoform X9

Conserved Domains (1) summary

cl12013
Location:5 → 238

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039083445.2 → XP_038939373.1 tyrosine-protein kinase Fer isoform X8

Conserved Domains (1) summary

cl12013
Location:5 → 238

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_008767367.4 → XP_008765589.1 tyrosine-protein kinase Fer isoform X1

See identical proteins and their annotated locations for XP_008765589.1

UniProtKB/Swiss-Prot

F1MA12, P09760

UniProtKB/TrEMBL

A0A140TAC4

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain
XM_039083436.2 → XP_038939364.1 tyrosine-protein kinase Fer isoform X4

UniProtKB/TrEMBL

A0A8I6ANB7

Conserved Domains (3) summary

cd10361
Location:279 → 364

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl12013
Location:1 → 63

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21453
Location:392 → 642

PKc_like; Protein Kinases, catalytic domain
XM_039083441.2 → XP_038939369.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain
XM_039083442.2 → XP_038939370.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain
XM_063267048.1 → XP_063123118.1 tyrosine-protein kinase Fer isoform X12
XM_039083439.1 → XP_038939367.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain
XM_039083438.1 → XP_038939366.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain
XM_039083444.1 → XP_038939372.1 tyrosine-protein kinase Fer isoform X7

UniProtKB/TrEMBL

F1LPI8

Conserved Domains (2) summary

cd10361
Location:84 → 169

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:197 → 447

PKc_like; Protein Kinases, catalytic domain
XM_039083440.1 → XP_038939368.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain
XM_039083443.1 → XP_038939371.1 tyrosine-protein kinase Fer isoform X6

Conserved Domains (2) summary

cd10361
Location:85 → 170

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:198 → 448

PKc_like; Protein Kinases, catalytic domain