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    Usp18 ubiquitin specific peptidase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312688, updated on 27-May-2024

    Summary

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    Symbol
    Usp18provided by RGD
    Full Name
    ubiquitin specific peptidase 18provided by RGD
    Primary source
    RGD:1359153
    See related
    Ensembl:ENSRNOG00000037198 AllianceGenome:RGD:1359153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ISG15-specific protease activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway; protein deubiquitination; and regulation of inflammatory response. Predicted to act upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 212.3), Spleen (RPKM 126.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp18 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156143770..156171292)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154471634..154499154)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153812312..153834374)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 8 Neighboring gene uncharacterized LOC120102509 Neighboring gene uncharacterized LOC102553072 Neighboring gene solute carrier family 6 member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy. Yuan L, et al. Neurosci Lett, 2023 Jul 27. PMID 37356565
    2. Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome. Meuwissen ME, et al. J Exp Med, 2016 Jun 27. PMID 27325888, Free PMC Article
    3. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Kim KI, et al. Mol Cell Biol, 2006 Jan. PMID 16382139, Free PMC Article
    4. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. Malakhov MP, et al. J Biol Chem, 2002 Mar 22. PMID 11788588
    5. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, et al. J Med Virol, 2017 Jul. PMID 28036111

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.
      Title: USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.
    2. USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
      Title: USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ISG15-specific peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to stilbenoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubl carboxyl-terminal hydrolase 18
    NP_001014080.1
    XP_038963593.1
    XP_038963594.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014058.2 → NP_001014080.1  ubl carboxyl-terminal hydrolase 18

      See identical proteins and their annotated locations for NP_001014080.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      F1LNS1, Q6AYC7
      Related
      ENSRNOP00000053020.3, ENSRNOT00000056174.5
      Conserved Domains (2) summary
      cd02257
      Location:53 → 358
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:52 → 357
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156143770..156171292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107666.2 → XP_038963594.1  ubl carboxyl-terminal hydrolase 18 isoform X2

      UniProtKB/TrEMBL
      A6ILC0
      Conserved Domains (1) summary
      pfam00443
      Location:52 → 279
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_039107665.1 → XP_038963593.1  ubl carboxyl-terminal hydrolase 18 isoform X1

      UniProtKB/TrEMBL
      A6ILC1
      Conserved Domains (1) summary
      cd02257
      Location:50 → 288
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    Nucleotide Protein Strain
    Heading Accession and Version

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