Rac2 Rac family small GTPase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rac2provided by RGD
Official Full Name: Rac family small GTPase 2provided by RGD
Primary source: RGD:1307568
See related: Ensembl:ENSRNOG00000007350 AllianceGenome:RGD:1307568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including cytosol; lamellipodium; and nuclear envelope. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Predicted to colocalize with actin filament. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1062.1), Spleen (RPKM 912.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111981825..112009201, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110101344..110128718, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119769708..119797111, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that CCL2, NF-kappaB1, RAC2, FCER1G and C1Q may contribute to the generation of neuropathic pain after sciatic nerve injury via immune and defense pathways.
Title: Gene expression profile changes in rat dorsal horn after sciatic nerve injury.
There is a functional interaction between AIF-1 and Rac2 in VSMC leading to Rac2 activation and a potential function for Rac2 in inflammation-driven VSMC response to injury.
Title: Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte enucleation	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related C3 botulinum toxin substrate 2

Names: RAS-related C3 botulinum substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008384.1 → NP_001008385.1 ras-related C3 botulinum toxin substrate 2

See identical proteins and their annotated locations for NP_001008385.1

Status: PROVISIONAL

Source sequence(s)

BC086399

UniProtKB/TrEMBL

F7EM94, Q5U1Y2

Related

ENSRNOP00000009994.4, ENSRNOT00000009994.6

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111981825..112009201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595021.3 → XP_017450510.1 ras-related C3 botulinum toxin substrate 2 isoform X2

UniProtKB/TrEMBL

A0A8I6G820
XM_006242028.4 → XP_006242090.1 ras-related C3 botulinum toxin substrate 2 isoform X1

See identical proteins and their annotated locations for XP_006242090.1

UniProtKB/TrEMBL

F7EM94, Q5U1Y2

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3