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    YHC1 Yhc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851005, updated on 17-May-2024

    Summary

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    Gene symbol
    YHC1
    Gene description
    Yhc1p
    Primary source
    FungiDB:YLR298C
    Locus tag
    YLR298C
    See related
    SGD:S000004289; AllianceGenome:SGD:S000004289; VEuPathDB:YLR298C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity and pre-mRNA 5'-splice site binding activity. Involved in mRNA 5'-splice site recognition and positive regulation of RNA binding activity. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YHC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (724721..725416, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gamma-glutamyltransferase Neighboring gene glucan 1,3-beta-glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing. Du H, et al. Nature, 2002 Sep 5. PMID 12214237
    2. Identification and characterization of a yeast homolog of U1 snRNP-specific protein C. Tang J, et al. EMBO J, 1997 Jul 1. PMID 9233817, Free PMC Article
    3. Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor. Chen JY, et al. Mol Cell, 2001 Jan. PMID 11172727
    4. Dynamics and consequences of spliceosome E complex formation. Larson JD, et al. Elife, 2017 Aug 22. PMID 28829039, Free PMC Article
    5. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. Kofoed M, et al. G3 (Bethesda), 2015 Jul 14. PMID 26175450, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A report on structure-function relations of the Yhc1 subunit and novel genetic interactions of the Yhc1 N-domain mutations.
      Title: Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 5'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 5'-splice site binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 5'-splice site recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 5'-splice site recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of commitment complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of commitment complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yhc1p
    NP_013401.1
    • Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      724721..725416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182186.1 → NP_013401.1  TPA: Yhc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYU2, Q05900
      UniProtKB/TrEMBL
      A0A6A5PV08, A7A1H9, B3RHH7, B5VNK0, C7GVU1, C8ZDR0, N1NZZ4
      Conserved Domains (1) summary
      COG5136
      Location:1 → 217
      COG5136; U1 snRNP-specific protein C [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5ZWN_R.1
    6N7P_B.1
    6N7R_B.1
    6N7X_B.1
    Q05900.1

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