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    GUF1 GTPase GUF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850996, updated on 17-May-2024

    Summary

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    Gene symbol
    GUF1
    Gene description
    GTPase GUF1
    Primary source
    FungiDB:YLR289W
    Locus tag
    YLR289W
    See related
    SGD:S000004280; AllianceGenome:SGD:S000004280; VEuPathDB:YLR289W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity and mitochondrial ribosome binding activity. Involved in positive regulation of translation. Located in mitochondrial matrix. Used to study West syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GUF1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (715089..717026)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S30A Neighboring gene Mec3p Neighboring gene ubiquinone biosynthesis protein COQ11 Neighboring gene translation initiation factor eIF2B subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1. Alfaiz AA, et al. Eur J Hum Genet, 2016 Jul. PMID 26486472, Free PMC Article
    2. Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. Prestele M, et al. Mol Biol Cell, 2009 May. PMID 19339279, Free PMC Article
    3. The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions. Bauerschmitt H, et al. J Biol Chem, 2008 Jun 20. PMID 18442968
    4. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Butcher RA, et al. Nat Chem Biol, 2006 Feb. PMID 16415861
    5. GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Kiser GL, et al. Yeast, 1995 Oct. PMID 8553703

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Guf1 promotes mitochondrial protein synthesis under suboptimal conditions
      Title: The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    GTPase GUF1
    NP_013392.1
    • Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      715089..717026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182177.1 → NP_013392.1  TPA: GTPase GUF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013392.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A1H2, B3RHG9, C8ZDQ3, D6VYT5, P46943, Q05891
      UniProtKB/TrEMBL
      A0A8H4F8I9, B5VNJ5, C7GVU8, G2WJB3, N1NYI7
      Conserved Domains (1) summary
      COG0481
      Location:38 → 645
      LepA; Translation elongation factor EF-4, membrane-bound GTPase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46943.2

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