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    AIM24 Aim24p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853543, updated on 9-Jun-2024

    Summary

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    Gene symbol
    AIM24
    Gene description
    Aim24p
    Primary source
    FungiDB:YJR080C
    Locus tag
    YJR080C
    See related
    SGD:S000003841; AllianceGenome:SGD:S000003841; VEuPathDB:YJR080C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP26
    Summary
    Involved in inner mitochondrial membrane organization. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AIM24 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (580432..581616, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mir1p Neighboring gene dioxygenase BNA2 Neighboring gene uncharacterized protein Neighboring gene Eaf6p Neighboring gene Acf4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration. Deckers M, et al. FEBS Lett, 2014 Aug 25. PMID 24928273
    2. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article
    3. A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis. Chen L, et al. Mol Microbiol, 2018 Dec. PMID 30251372
    4. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Alkhaja AK, et al. Mol Biol Cell, 2012 Jan. PMID 22114354, Free PMC Article
    5. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In conclusion, Aim24 by interacting with the MICOS complex plays a key role in mitochondrial architecture, composition and function.
      Title: Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture.
    2. Aim24 has a function in stabilizing the respiratory chain supercomplexes
      Title: Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aim24p
    NP_012614.1
    • Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      580432..581616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181738.1 → NP_012614.1  TPA: Aim24p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LQG6, C8ZBM7, D6VWQ0, P47127
      UniProtKB/TrEMBL
      A0A6L0Z712, G2WH84
      Conserved Domains (1) summary
      cl00884
      Location:49 → 322
      AIM24; Mitochondrial biogenesis AIM24
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47127.1

    Gene LinkOut

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