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    IMD4 IMP dehydrogenase IMD4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854948, updated on 9-Jun-2024

    Summary

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    Gene symbol
    IMD4
    Gene description
    IMP dehydrogenase IMD4
    Primary source
    FungiDB:YML056C
    Locus tag
    YML056C
    See related
    SGD:S000004520; AllianceGenome:SGD:S000004520; VEuPathDB:YML056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Predicted to be involved in GTP biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IMD4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (162194..164176, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase inhibiting protein SML1 Neighboring gene calcineurin catalytic subunit A Neighboring gene ncRNA Neighboring gene signal peptidase complex subunit SPC2 Neighboring gene L-lactate dehydrogenase (cytochrome)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. Köhler GA, et al. J Bacteriol, 1997 Apr. PMID 9079920, Free PMC Article
    2. Proximity to the Promoter and Terminator Regions Regulates the Transcription Enhancement Potential of an Intron. Dwyer K, et al. Front Mol Biosci, 2021. PMID 34291091, Free PMC Article
    3. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. Hyle JW, et al. J Biol Chem, 2003 Aug 1. PMID 12746440, Free PMC Article
    4. Participation of yeast inosine 5'-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand. Cornuel JF, et al. Biochimie, 2002 Apr. PMID 12106905
    5. IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Park JH, et al. Biochem Biophys Res Commun, 2010 Feb 19. PMID 20097157

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IMP dehydrogenase IMD4
    NP_013656.1
    • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      162194..164176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182414.1 → NP_013656.1  TPA: IMP dehydrogenase IMD4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB8, P50094, Q2VQW8
      UniProtKB/TrEMBL
      C8ZEF1, G2WK00
      Conserved Domains (1) summary
      PTZ00314
      Location:21 → 519
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50094.1

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