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    Abca8b ATP-binding cassette, sub-family A member 8b [ Mus musculus (house mouse) ]

    Gene ID: 27404, updated on 12-May-2024

    Summary

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    Official Symbol
    Abca8bprovided by MGI
    Official Full Name
    ATP-binding cassette, sub-family A member 8bprovided by MGI
    Primary source
    MGI:MGI:1351668
    See related
    Ensembl:ENSMUSG00000020620 AllianceGenome:MGI:1351668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abca8
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; positive regulation of cholesterol efflux; and sphingomyelin biosynthetic process. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; eye; limb; male reproductive gland or organ; and nervous system. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 22.7), liver adult (RPKM 4.4) and 12 other tissues See more
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    Genomic context

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    See Abca8b in Genome Data Viewer
    Location:
    11 E1; 11 72.88 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109823016..109886642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109932206..109996274, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700023C21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109721516-109721718 Neighboring gene STARR-positive B cell enhancer ABC_E3034 Neighboring gene STARR-seq mESC enhancer starr_31030 Neighboring gene STARR-seq mESC enhancer starr_31031 Neighboring gene STARR-seq mESC enhancer starr_31032 Neighboring gene predicted gene, 39444 Neighboring gene STARR-seq mESC enhancer starr_31033 Neighboring gene ATP-binding cassette, sub-family A member 8a Neighboring gene ATP-binding cassette, sub-family A member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver. Sasaki K, et al. Mol Pharm, 2018 Feb 5. PMID 29300488
    2. ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels. Trigueros-Motos L, et al. Arterioscler Thromb Vasc Biol, 2017 Nov. PMID 28882873
    3. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi M, et al. Clin Exp Pharmacol Physiol, 2005 Dec. PMID 16445568
    4. Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes. Annilo T, et al. Mamm Genome, 2003 Jan. PMID 12532264
    5. Quantitative trait loci for steady-state platelet count in mice. Cheung CC, et al. Mamm Genome, 2004 Oct. PMID 15520881

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study results suggest that mABCA8b/ABCA8 functions as a sinusoidal efflux transporter for at least cholesterol and taurocholate in mouse and human liver.
      Title: ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.
    2. ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels.
      Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingomyelin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ABC-type organic anion transporter ABCA8B
    Names
    ATP-binding cassette sub-family A member 8-B
    ATP-binding cassette, sub-family A (ABC1), member 8b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362749.2 → NP_001349678.1  ABC-type organic anion transporter ABCA8B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807245
      Consensus CDS
      CCDS88278.1
      Related
      ENSMUSP00000102280.3, ENSMUST00000106669.3
      Conserved Domains (1) summary
      TIGR01257
      Location:322 → 1534
      rim_protein; retinal-specific rim ABC transporter

    2. NM_001425480.1 → NP_001412409.1  ABC-type organic anion transporter ABCA8B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL807245
      UniProtKB/Swiss-Prot
      A2AM55, Q69ZY4, Q8BRQ1, Q8K440, Q9JL38
      UniProtKB/TrEMBL
      A2AM56

    3. NM_001425481.1 → NP_001412410.1  ABC-type organic anion transporter ABCA8B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807245

    4. NM_013851.4 → NP_038879.2  ABC-type organic anion transporter ABCA8B isoform 1

      See identical proteins and their annotated locations for NP_038879.2

      Status: VALIDATED

      Source sequence(s)
      AL807245
      Consensus CDS
      CCDS25587.1
      UniProtKB/Swiss-Prot
      A2AM55, Q69ZY4, Q8BRQ1, Q8K440, Q9JL38
      UniProtKB/TrEMBL
      A2AM56
      Related
      ENSMUSP00000020948.9, ENSMUST00000020948.15
      Conserved Domains (1) summary
      TIGR01257
      Location:265 → 1596
      rim_protein; retinal-specific rim ABC transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109823016..109886642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533461.5 → XP_006533524.1  ABC-type organic anion transporter ABCA8B isoform X3

      Conserved Domains (1) summary
      TIGR01257
      Location:265 → 1561
      rim_protein; retinal-specific rim ABC transporter

    2. XM_006533463.3 → XP_006533526.1  ABC-type organic anion transporter ABCA8B isoform X4

      See identical proteins and their annotated locations for XP_006533526.1

      UniProtKB/Swiss-Prot
      Q8K440
      Conserved Domains (1) summary
      TIGR01257
      Location:322 → 1534
      rim_protein; retinal-specific rim ABC transporter

    3. XM_030246047.1 → XP_030101907.1  ABC-type organic anion transporter ABCA8B isoform X6

      Conserved Domains (2) summary
      TIGR01257
      Location:277 → 818
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:505 → 726
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

    4. XM_006533464.5 → XP_006533527.1  ABC-type organic anion transporter ABCA8B isoform X5

      Conserved Domains (2) summary
      TIGR01257
      Location:265 → 789
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:479 → 702
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K440.2 GenPept UniProtKB/Swiss-Prot:Q8K440

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