Msl1 male specific lethal 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msl1provided by MGI
Official Full Name: male specific lethal 1provided by MGI
Primary source: MGI:MGI:1921276
See related: Ensembl:ENSMUSG00000052915 AllianceGenome:MGI:1921276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msl-1; 2810017F12Rik; 4121402D02Rik; 4930463F05Rik
Summary: Predicted to enable chromatin binding activity. Involved in histone H4-K16 acetylation. Located in nuclear speck. Is expressed in embryo. Orthologous to human MSL1 (MSL complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 22.2), testis adult (RPKM 20.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.67 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98684214..98698685)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98793508..98807862)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation.
Title: MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation.
Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3).
Title: PEG3 control on the mammalian MSL complex.
Studies identi fi ed a novel signal of nuclear localization (NLS) in all MSL1 protein isoforms and found that the combination of both NLS allows for its intra-nuclear focal accumulation and nuclear transport of TTC4 while all MSL1 isoforms affect H4K16Ac.
Title: Two distinct nuclear localization signals in mammalian MSL1 regulate its function.
Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.
Title: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
hampin may be linked to diverse regulatory processes in the nucleus
Title: Characterization of hampin/MSL1 as a node in the nuclear interactome.
Describes the primary structure of the protein hampin, which shares about 26% sequence identity with the Drosophila MSL1 protein. In mouse, at least five splice isoforms exist, two of which have restricted tissue specificity (testes).
Title: [Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

RH124358 (e-PCR)
- UniSTS:161180

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MSL complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of MSL complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: male-specific lethal 1 homolog

Names: MSL1-like 1; hampin; male-specific lethal 1-like 1; male-specific lethal-1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361931.1 → NP_001348860.1 male-specific lethal 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL590963

Consensus CDS

CCDS88248.1

Related

ENSMUSP00000103111.4, ENSMUST00000107487.10

Conserved Domains (1) summary

pfam15275
Location:461 → 577

PEHE; PEHE domain
NM_001361932.1 → NP_001348861.1 male-specific lethal 1 homolog isoform 3

Status: VALIDATED

Source sequence(s)

AK014463, AL590963, BC043039

Consensus CDS

CCDS88249.1

Related

ENSMUSP00000103109.2, ENSMUST00000107485.8
NM_001361933.1 → NP_001348862.1 male-specific lethal 1 homolog isoform 4

Status: VALIDATED

Source sequence(s)

AK015496, AL590963

Consensus CDS

CCDS88250.1

Related

ENSMUSP00000043328.7, ENSMUST00000037930.13

Conserved Domains (1) summary

pfam15275
Location:231 → 347

PEHE; PEHE domain
NM_001361934.1 → NP_001348863.1 male-specific lethal 1 homolog isoform 5

Status: VALIDATED

Source sequence(s)

AK161412, AL590963
NM_028722.3 → NP_082998.2 male-specific lethal 1 homolog isoform 1

See identical proteins and their annotated locations for NP_082998.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK014463, AL590963, BC058629

Consensus CDS

CCDS25364.1

UniProtKB/Swiss-Prot

A3KFP2, A3KFP4, Q27QB3, Q3TTE5, Q6PDM1, Q80XS0, Q8BPN3, Q9CXF9, Q9D5C9

Related

ENSMUSP00000042792.3, ENSMUST00000037915.9

Conserved Domains (1) summary

pfam15275
Location:477 → 593

PEHE; PEHE domain