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    Snx24 sorting nexing 24 [ Mus musculus (house mouse) ]

    Gene ID: 69226, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snx24provided by MGI
    Official Full Name
    sorting nexing 24provided by MGI
    Primary source
    MGI:MGI:1916476
    See related
    Ensembl:ENSMUSG00000024535 AllianceGenome:MGI:1916476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810011K15Rik; 5730433I16Rik
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle and membrane. Orthologous to human SNX24 (sorting nexin 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.5), limb E14.5 (RPKM 1.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx24 in Genome Data Viewer
    Location:
    18 D1; 18 29.0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53376877..53523994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53243933..53390922)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4250 Neighboring gene sorting nexin 2 Neighboring gene Rac GTPase-activating protein 1 pseudogene Neighboring gene predicted gene, 54042 Neighboring gene predicted gene, 57647 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44622 Neighboring gene peptidylprolyl isomerase C Neighboring gene STARR-seq mESC enhancer starr_44623 Neighboring gene predicted gene, 41726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Mizutani R, et al. Cell Signal, 2009 Nov. PMID 19576982
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370761.1 → NP_001357690.1  sorting nexin-24

      Status: VALIDATED

      Source sequence(s)
      AC109291, AC148020
      Consensus CDS
      CCDS29251.1
      UniProtKB/Swiss-Prot
      Q9CRB0
      Related
      ENSMUSP00000025417.9, ENSMUST00000025417.9
      Conserved Domains (1) summary
      cd06880
      Location:1 → 111
      PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

    2. NM_029394.4 → NP_083670.1  sorting nexin-24

      See identical proteins and their annotated locations for NP_083670.1

      Status: VALIDATED

      Source sequence(s)
      AC109291, AC148020
      Consensus CDS
      CCDS29251.1
      UniProtKB/Swiss-Prot
      Q9CRB0
      Related
      ENSMUSP00000131423.2, ENSMUST00000165032.9
      Conserved Domains (1) summary
      cd06880
      Location:1 → 111
      PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      53376877..53523994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246995.4 → XP_011245297.1  sorting nexin-24 isoform X1

      Conserved Domains (1) summary
      cl02563
      Location:79 → 127
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_036161271.1 → XP_036017164.1  sorting nexin-24 isoform X2

      Conserved Domains (1) summary
      cl02563
      Location:1 → 84
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RNA

    1. XR_004939886.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRB0.1 GenPept UniProtKB/Swiss-Prot:Q9CRB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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