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    RCY1 Rcy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853226, updated on 17-May-2024

    Summary

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    Gene symbol
    RCY1
    Gene description
    Rcy1p
    Primary source
    FungiDB:YJL204C
    Locus tag
    YJL204C
    See related
    SGD:S000003740; AllianceGenome:SGD:S000003740; VEuPathDB:YJL204C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNARE binding activity. Involved in early endosome to Golgi transport; endocytic recycling; and endocytosis. Located in Golgi apparatus; endosome; and site of polarized growth. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RCY1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (50629..53151, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nce101p Neighboring gene Prp21p Neighboring gene Ecm25p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. Wiederkehr A, et al. J Cell Biol, 2000 Apr 17. PMID 10769031, Free PMC Article
    2. Interaction of the phospholipid flippase Drs2p with the F-box protein Rcy1p plays an important role in early endosome to trans-Golgi network vesicle transport in yeast. Hanamatsu H, et al. J Biochem, 2014 Jan. PMID 24272750
    3. Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway. Kojima A, et al. Biochim Biophys Acta, 2012 Feb. PMID 22210050
    4. Endocytic uptake of fluorescence labelled DNA in yeast. Riechers SP, et al. J Basic Microbiol, 2010 Feb. PMID 20175124
    5. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Galan JM, et al. Mol Cell Biol, 2001 May. PMID 11287615, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results reveal the involvement of Rcy1 in chromosome regulation and another regulatory pathway controlling the Cse4 level and activity.
      Title: The F-box Protein Rcy1 Is Involved in the Degradation of Histone H3 Variant Cse4 and Genome Maintenance.
    2. Ypt31/32 GTPases regulate the function of Rcy1 in the phosphorylation and/or ubiquitination of proteins that recycle through the Golgi
      Title: Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling.
    3. Ypt31p/32p-Rcy1p pathway regulates putative phospholipid translocases to promote formation of vesicles destined for the trans-Golgi network from early endosomes.
      Title: Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rcy1p
    NP_012331.1
    • F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      50629..53151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181637.1 → NP_012331.1  TPA: Rcy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ0, P39530, P39531, P87193
      UniProtKB/TrEMBL
      A0A8H4BY80, N1P376
      Conserved Domains (1) summary
      pfam07393
      Location:101 → 827
      Sec10; Exocyst complex component Sec10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39531.4

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