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    GPI11 mannose-ethanolamine phosphotransferase GPI11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851896, updated on 17-May-2024

    Summary

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    Gene symbol
    GPI11
    Gene description
    mannose-ethanolamine phosphotransferase GPI11
    Primary source
    FungiDB:YDR302W
    Locus tag
    YDR302W
    See related
    SGD:S000002710; AllianceGenome:SGD:S000002710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GPI11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1067731..1068390)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glutamate 5-kinase Neighboring gene cleavage/polyadenylation factor CFT1 Neighboring gene Rsc3p Neighboring gene peptidylprolyl isomerase family protein CPR5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Taron CH, et al. Mol Biol Cell, 2000 May. PMID 10793139, Free PMC Article
    2. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Grimme SJ, et al. J Biol Chem, 2001 Jul 20. PMID 11356840
    3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
    4. Exploring genetic suppression interactions on a global scale. van Leeuwen J, et al. Science, 2016 Nov 4. PMID 27811238, Free PMC Article
    5. The synthetic genetic interaction spectrum of essential genes. Davierwala AP, et al. Nat Genet, 2005 Oct. PMID 16155567

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannose-ethanolamine phosphotransferase GPI11
    NP_010588.1
    • ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1067731..1068390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180610.1 → NP_010588.1  TPA: mannose-ethanolamine phosphotransferase GPI11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST1, Q06636
      UniProtKB/TrEMBL
      A0A6A5PYW4, A6ZYQ0, B3LFZ3, B5VGI1, C7GQV2, C8Z5L4, G2WB40, N1P8L0
      Conserved Domains (1) summary
      pfam06699
      Location:50 → 216
      PIG-F; GPI biosynthesis protein family Pig-F
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06636.1

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