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    Tmem220 transmembrane protein 220 [ Mus musculus (house mouse) ]

    Gene ID: 338369, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem220provided by MGI
    Official Full Name
    transmembrane protein 220provided by MGI
    Primary source
    MGI:MGI:2443691
    See related
    Ensembl:ENSMUSG00000050270 AllianceGenome:MGI:2443691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM220 (transmembrane protein 220). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 4.1), liver E18 (RPKM 3.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem220 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66915959..66927818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67025154..67035312)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 like Neighboring gene STARR-positive B cell enhancer ABC_E8414 Neighboring gene STARR-seq mESC enhancer starr_29788 Neighboring gene predicted gene 12299 Neighboring gene STARR-seq mESC enhancer starr_29789 Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene myosin, heavy polypeptide 3, skeletal muscle, embryonic Neighboring gene microRNA 6923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130169, MGC130170, A730055C05Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 220

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291042.1 → NP_001277971.1  transmembrane protein 220 isoform 2

      See identical proteins and their annotated locations for NP_001277971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK043094, AK078505
      Consensus CDS
      CCDS70209.1
      UniProtKB/Swiss-Prot
      Q2TB06, Q8BP07, Q8C936
      Related
      ENSMUSP00000057366.6, ENSMUST00000061786.6
      Conserved Domains (1) summary
      pfam15071
      Location:29 → 118
      TMEM220; Transmembrane family 220, helix

    2. NM_001291043.1 → NP_001277972.1  transmembrane protein 220 isoform 3

      See identical proteins and their annotated locations for NP_001277972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK078505, BC110629
      UniProtKB/Swiss-Prot
      Q8BP07
      Conserved Domains (1) summary
      pfam15071
      Location:29 → 102
      TMEM220; Transmembrane family 220, helix

    3. NM_177392.3 → NP_796366.1  transmembrane protein 220 isoform 1

      See identical proteins and their annotated locations for NP_796366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK043094, AK078505
      Consensus CDS
      CCDS24850.1
      UniProtKB/Swiss-Prot
      Q8BP07
      Related
      ENSMUSP00000078084.6, ENSMUST00000079077.12
      Conserved Domains (1) summary
      pfam15071
      Location:29 → 142
      TMEM220; Transmembrane family 220, helix

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      66915959..66927818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156786.1 → XP_036012679.1  transmembrane protein 220 isoform X1

      Conserved Domains (1) summary
      pfam15071
      Location:32 → 108
      TMEM220; Transmembrane family 220, helix
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP07.1 GenPept UniProtKB/Swiss-Prot:Q8BP07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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