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    RRI2 Rri2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854032, updated on 17-May-2024

    Summary

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    Gene symbol
    RRI2
    Gene description
    Rri2p
    Primary source
    FungiDB:YOL117W
    Locus tag
    YOL117W
    See related
    SGD:S000005477; AllianceGenome:SGD:S000005477; VEuPathDB:YOL117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CSN10
    Summary
    Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and protein deneddylation. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRI2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (97551..99488)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mch4p Neighboring gene uncharacterized protein Neighboring gene Msn1p Neighboring gene non-canonical poly(A) polymerase PAP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research. Harshuk-Shabso D, et al. Biomolecules, 2021 Mar 25. PMID 33806190, Free PMC Article
    2. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. Licursi V, et al. FEBS J, 2014 Jan. PMID 24164706
    3. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462
    4. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. Maytal-Kivity V, et al. EMBO Rep, 2002 Dec. PMID 12446563, Free PMC Article
    5. Conservation of the COP9/signalosome in budding yeast. Wee S, et al. BMC Genet, 2002 Aug 20. PMID 12186635, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rri2p
    NP_014524.1
    • Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      97551..99488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183371.1 → NP_014524.1  TPA: Rri2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V0, Q12348
      UniProtKB/TrEMBL
      A0A8H4BUR3, G2WMB9, N1P3T3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12348.1

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