U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SPC3 signal peptidase complex subunit SPC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850755, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    SPC3
    Gene description
    signal peptidase complex subunit SPC3
    Primary source
    FungiDB:YLR066W
    Locus tag
    YLR066W
    See related
    SGD:S000004056; AllianceGenome:SGD:S000004056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SPC3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (267169..267723)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Per33p Neighboring gene Snd2p Neighboring gene Pet309p Neighboring gene Fyv7p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases. VanValkenburgh C, et al. J Biol Chem, 1999 Apr 23. PMID 10206957
    2. The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. Meyer HA, et al. J Biol Chem, 1997 May 16. PMID 9148931
    3. Cotranslational Targeting and Posttranslational Translocation can Cooperate in Spc3 Topogenesis. Jung SJ, et al. J Mol Biol, 2021 Sep 3. PMID 34153287
    4. Characterization of Candida albicans orthologue of the Saccharomyces cerevisiae signal-peptidase-subunit encoding gene SPC3. De La Rosa JM, et al. Yeast, 2004 Jul 30. PMID 15300682
    5. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal peptidase complex subunit SPC3
    NP_013167.1
    • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      267169..267723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181953.1 → NP_013167.1  TPA: signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY67, Q12133
      UniProtKB/TrEMBL
      A0A6A5PW30, A7A0X1, B3LT36, B5VMZ8, C7GQP1, C8ZD38, G2WIQ8, N1P108
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 177
      SPC22; Signal peptidase subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12133.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous