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    TRP5 tryptophan synthase TRP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852858, updated on 17-May-2024

    Summary

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    Gene symbol
    TRP5
    Gene description
    tryptophan synthase TRP5
    Primary source
    FungiDB:YGL026C
    Locus tag
    YGL026C
    See related
    SGD:S000002994; AllianceGenome:SGD:S000002994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tryptophan synthase activity. Involved in tryptophan biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TRP5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (446412..448535, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative glucan endo-1,3-beta-D-glucosidase Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene Pgd1p Neighboring gene Pib2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRYPTOPHAN SYNTHETASE MUTANTS OF YEAST: ACTION OF A SUPER-SUPPRESSOR IN RELATION TO ALLELIC MAPPING AND COMPLEMENTATION. UCRL-11191. MANNEY TR. UCRL US At Energy Comm, 1964 Jan 8. PMID 24547113
    2. Saccharomyces cerevisiae genes involved in survival of heat shock. Jarolim S, et al. G3 (Bethesda), 2013 Dec 9. PMID 24142923, Free PMC Article
    3. Characterization of the trp5-27 allele used to monitor drug-induced mitotic gene conversion in the Saccharomyces cerevisiae tester strain D7. Ehrenhofer-Murray AE, et al. Mutagenesis, 1994 Jul. PMID 7968581
    4. Purification and properties of tryptophan synthase from baker's yeast (Saccharomyces cerevisiae). Bailey CJ, et al. Biochem J, 1983 Jan 1. PMID 6342605, Free PMC Article
    5. Yeast gene TRP5: structure, function, regulation. Zalkin H, et al. J Biol Chem, 1982 Feb 10. PMID 6276387

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tryptophan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    tryptophan synthase TRP5
    NP_011489.1
    • Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      446412..448535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180891.1 → NP_011489.1  TPA: tryptophan synthase TRP5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011489.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB2, P00931
      UniProtKB/TrEMBL
      A0A8H4FBM2, B3LIN9, C8Z8L6, N1P5K3
      Conserved Domains (2) summary
      PRK04346
      Location:305 → 688
      PRK04346; tryptophan synthase subunit beta; Validated
      pfam00290
      Location:9 → 259
      Trp_syntA; Tryptophan synthase alpha chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00931.1

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