CanA1 Calcineurin A1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CanA1provided by FlyBase
Official Full Name: Calcineurin A1provided by FlyBase
Primary source: FLYBASE:FBgn0010015
Locus tag: Dmel_CG1455
See related: AllianceGenome:FB:FBgn0010015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Can; CaN; CAN A1/PP2B; canA; canA1; Cana1; CaNA1; CG1455; CnA; CNA1; CnnA21EF; D14; DmCanA1-100B; Dmel\CG1455; pMY4; PP2B; PP2B 21EF; PpD14
Summary: Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including medium-term memory; negative regulation of epidermal growth factor receptor signaling pathway; and response to nitric oxide. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in aortic valve stenosis and schizophrenia. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 100B1-100B1; 3-102 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31039374..31046821)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26865096..26872543)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of Ca[2+] phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
Title: Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
Ca2+ administration prevents alpha-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
Title: Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
Title: Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
results suggest a key role for calcineurin in cardiac remodeling during long-term hypoxia with implications for diseases of chronic hypoxia, and it likely contributes to mechanisms underlying these disease states.
Title: Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.
upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD.
Title: Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
calcineurin, upon activation by Ca(2+)-calmodulin, cooperates with other factors to negatively regulate Egf receptor signaling at the level of sprouty and the GTPase-activating protein Gap1
Title: The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 31045753-31045869 mobile_element_type = transposon:INE-1{}3519

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in medium-term memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nitric oxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nitric oxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: calcineurin A1

Names: CG1455-PA; CG1455-PB; CG1455-PD; CanA1-PA; CanA1-PB; CanA1-PD; calcineurin; calcineurin A; protein phosphatase D14; protein phosphatase from PCR fragment D14

NP_001247377.1

EC 3.-.-.-

EC 3.1.3.16

NP_001247378.2

EC 3.-.-.-

EC 3.1.3.16

NP_524600.3

EC 3.-.-.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31039374..31046821

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260449.2 → NP_001247378.2 calcineurin A1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247378.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P48456, Q8MQN3, Q9TY69, Q9VA20

UniProtKB/TrEMBL

A0A0B4K6V6

Conserved Domains (2) summary

smart00156
Location:98 → 369

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:81 → 385

MPP_PP2B; PP2B, metallophosphatase domain
NM_079861.4 → NP_524600.3 calcineurin A1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524600.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P48456, Q8MQN3, Q9TY69, Q9VA20

UniProtKB/TrEMBL

A0A0B4K6V6

Related

FBpp0085094

Conserved Domains (2) summary

smart00156
Location:98 → 369

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:81 → 385

MPP_PP2B; PP2B, metallophosphatase domain
NM_001260448.2 → NP_001247377.1 calcineurin A1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247377.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6N5

Conserved Domains (2) summary

smart00156
Location:98 → 369

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:81 → 385

MPP_PP2B; PP2B, metallophosphatase domain