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    mxc multi sex combs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31869, updated on 10-May-2024

    Summary

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    Official Symbol
    mxcprovided by FlyBase
    Official Full Name
    multi sex combsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260789
    Locus tag
    Dmel_CG12124
    See related
    AllianceGenome:FB:FBgn0260789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12058; CG12124; Dmel\CG12124; dNPAT; l(1)mbn; MPM-2; mpm2; MPM2; Mxc; MXC; NPAT
    Old locus tag
    Dmel_CG12058
    Summary
    Involved in hemocyte differentiation and hemocyte proliferation. Located in histone locus body. Is expressed in gonad; larval ventral nerve cord; and organism. Used to study hematologic cancer. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mxc in Genome Data Viewer
    Location:
    8D2-8D2; 1-27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9236801..9243467, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9130834..9137500, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene La related protein 7 Neighboring gene almondex Neighboring gene Downstream of raf1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile. Posukh OV, et al. Epigenetics Chromatin, 2017 Dec 1. PMID 29191233, Free PMC Article
    2. Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster. Landais S, et al. Cell Rep, 2014 May 8. PMID 24746823, Free PMC Article
    3. A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the Drosophila egg. Potter-Birriel JM, et al. J Cell Sci, 2021 Feb 11. PMID 33408246, Free PMC Article
    4. Superresolution light microscopy of the Drosophila histone locus body reveals a core-shell organization associated with expression of replication-dependent histone genes. Kemp JP Jr, et al. Mol Biol Cell, 2021 Apr 19. PMID 33788585, Free PMC Article
    5. Drosophila histone locus body assembly and function involves multiple interactions. Koreski KP, et al. Mol Biol Cell, 2020 Jul 1. PMID 32401666, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhancement of leukemia-like phenotypes in Drosophila mxc mutant larvae due to activation of the RAS-MAP kinase cascade possibly via down-regulation of DE-cadherin.
      Title: Enhancement of leukemia-like phenotypes in Drosophila mxc mutant larvae due to activation of the RAS-MAP kinase cascade possibly via down-regulation of DE-cadherin.
    2. The Drosophila abnormal chromosome segregation leading to chromosomal instability (CIN) development results from a loss of chromosome integrity caused by diminished canonical histone levels in mxc mutants.
      Title: Mutations in mxc Tumor-Suppressor Gene Induce Chromosome Instability in Drosophila Male Meiosis.
    3. Multiple domains of the Mxc protein promote histone locus body assembly in order to concentrate factors required for histone mRNA biosynthesis.
      Title: Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in hemocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in histone locus body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multi sex combs
    Names
    CG12124-PA
    CG12124-PB
    lethal(1)malignant blood neoplasm
    multiple sex combs
    mxc-PA
    mxc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9236801..9243467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132320.3 → NP_572548.1  multi sex combs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP21, Q9W363
      Related
      FBpp0071267
      Conserved Domains (1) summary
      PTZ00108
      Location:1414 → 1643
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. NM_001298114.1 → NP_001285043.1  multi sex combs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP21, Q9W363
      Conserved Domains (1) summary
      PTZ00108
      Location:1414 → 1643
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W363 Q9W363

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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